Does Extensive Upper Abdomen Surgery During Primary Cytoreduction Impact on Long-term Quality of Life?

Abstract

Upper abdomen surgery is a feasible and safe therapeutic option. Patients present same times of beginning of chemotherapy without an increase in chemorelated toxicities and experience the same general quality of life.

Patient-Reported Outcomes After Extensive (Ultraradical) Surgery for Ovarian Cancer: Results From a Prospective Longitudinal Feasibility Study

“…One study with 89 patients did attempt to compare PRO after standard and extensive surgery, but the questionnaires were only taken at the first follow-up appointment after completion of all treatments, lacking information on trend of PRO across a certain time frame. 23 The study reported no statistical differences in major surgical complication rates (15% vs 10%) and no severe chemotherapy-related toxicities. Patientreported outcome scores were comparable in both groups.…”

Quality of life from cytoreductive surgery in advanced ovarian cancer: Investigating the association between disease burden and surgical complexity in the international, prospective, SOCQER‐2 cohort study

“…Our methodologically robust multicentre study confirms findings from smaller single‐centre studies. 24 , 43 …”

“…Our methodologically robust multicentre study confirms findings from smaller single-centre studies. 24,43 Those undergoing high-SCS procedures had significantly greater disease burden and more upper abdominal disease, but patients with these disease characteristics also underwent surgery of low or intermediate complexity. As some women with comparably high disease burden would not have been offered surgery, understanding the QoL and survival of these patients not undergoing surgery is essential if the true value or detriment from high-SCS surgery is to be assessed.…”

Predictors of postoperative morbidity after cytoreduction for advanced ovarian cancer: Analysis and management of complications in upper abdominal surgery

“…If on one hand complex surgery for ovarian cancer has increased direct medical costs, it appears to have provided good value for money spent [11] without compromising long-term quality of life [12]. However, the upper abdominal surgical procedures have made it necessary to know and manage related complications [6].…”