Does exposure to environmental 2,4-dichlorophenoxyacetic acid concentrations increase mortality rate in animals? A meta-analytic review

Silva, Ana Paula Da; Morais, Elizete Rodrigues; Oliveira, Elton Celton de; Ghisi, Nédia de Castilhos

doi:10.1016/j.envpol.2022.119179

Cited by 18 publications

(9 citation statements)

References 74 publications

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“…Furthermore, PCDD/F congener profiles in D5 were similar to those in the soil samples (except for P8, which had a high proportion of OCDD) based on the correlation analysis of congener profiles (r > 0.88, p < 0.01). The 2,4-D butyl ester is an auxinic herbicide widely used in agriculture, and that can effectively control weeds [ 5 , 56 ]. Perhaps similar 2,4-D products have been used in this study area.…”

Section: Resultsmentioning

confidence: 99%

PCBs, PCNs, and PCDD/Fs in Soil around an Industrial Park in Northwest China: Levels, Source Apportionment, and Human Health Risk

et al. 2023

IJERPH

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The concentrations of polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) were determined in soil samples collected around an industrial park in Northwest China, to investigate the potential impacts of park emissions on the surrounding environment. The total concentration ranges of PCBs, PCNs, and PCDD/Fs in the soil samples were in 13.2–1240, 141–832, and 3.60–156 pg/g, respectively. The spatial distribution and congener patterns of PCBs, PCNs, and PCCD/Fs indicated that there might be multiple contamination sources in the study area, so source apportionments of PCBs, PCNs, and PCCD/Fs were performed by a positive matrix factorization model based on the concentrations of all target congeners together. The results revealed that these highly chlorinated congeners (CB-209, CN-75, and OCDF) might be derived from phthalocyanine pigments, the legacy of Halowax 1051 and 2,4-D products, which together contributed nearly half of the total concentration of target compounds (44.5%). In addition to highly chlorinated congeners, the local industrial thermal processes were mainly responsible for the contamination of PCBs, PCNs, and PCDD/Fs in the surrounding soil. The total carcinogenic risk of PCBs, PCNs, and PCDD/Fs in a few soil samples (0.22 × 10−6, 0.32 × 10−6, and 0.40 × 10−6) approached the threshold of potential carcinogenic risk (1.0 × 10−6). Since these pollutants can continuously accumulate in the soil, the contamination of PCBs, PCNs, and PCDD/Fs in surrounding soil deserves continuous attention.

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Section: Resultsmentioning

confidence: 99%

PCBs, PCNs, and PCDD/Fs in Soil around an Industrial Park in Northwest China: Levels, Source Apportionment, and Human Health Risk

et al. 2023

IJERPH

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“…Most acute toxicity tests have been carried out using the technical grade of an active ingredient. Thus, there is a clear need for further studies to evaluate the effects of commercial formulations that are enriched with co-formulates to make the active ingredient more stable and active over a longer period of time (Mesnage and Antoniou 2018 ), analogously to what has been demonstrated for other classes of compounds (Costas-Ferreira et al 2022 ; Da Silva et al 2022 ). Based on the principle of three Rs—Replacement, Reduction and Refinement—we suggest the use of the yeast Saccharomyces cerevisiae as an alternative eukaryotic model for future toxicological studies (Braconi et al 2016 ).…”

Section: Perspectives For Future Researchmentioning

confidence: 96%

Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms

Giglio

Vommaro

2022

Environ Sci Pollut Res

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The widespread use of herbicides has increased concern about the hazards and risks to animals living in terrestrial and aquatic ecosystems. A comprehensive understanding of their effective action at different levels of biological organization is critical for establishing guidelines to protect ecosystems and human health. Dinitroanilines are broad-spectrum pre-emergence herbicides currently used for weed control in the conventional agriculture. They are considered extremely safe agrochemicals because they act specifically on tubulin proteins and inhibit shoot and root growth of plants. However, there is a lack of toxicity information regarding the potential risk of exposure to non-target organisms. The aim of the present review is to focus on side effects of the most commonly used active ingredients, e.g. pendimethalin, oryzalin, trifluralin and benfluralin, on animal non-target cells of invertebrates and vertebrates. Acute toxicity varies from slightly to high in terrestrial and aquatic species (i.e. nematodes, earthworms, snails, insects, crustaceans, fish and mammals) depending on the species-specific ability of tested organisms to adsorb and discharge toxicants. Cytotoxicity, genotoxicity and activation of oxidative stress pathways as well as alterations of physiological, metabolic, morphological, developmental and behavioural traits, reviewed here, indicate that exposure to sublethal concentrations of active ingredients poses a clear hazard to animals and humans. Further research is required to evaluate the molecular mechanisms of action of these herbicides in the animal cell and on biological functions at multiple levels, from organisms to communities, including the effects of commercial formulations.

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“…Being widespread and highly soluble, 2,4-D and its transformation products have polluted natural water and soil resources [1]. Moreover, 2,4-D was reported to stand behind the cancer-disease development in mammals, as well as endocrine and central nervous system disorders [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Removal of 2,4-Dichlorophenoxyacetic Acid from Aqueous Solutions Using Al2O3/Graphene Oxide Granules Prepared by Spray-Drying Method

Kurmysheva,

Kuznetsova,

Vedenyapina

et al. 2024

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Within this study, aluminum oxide granules with 0.25%vol. of graphene oxide were prepared by a spray-drying method to make an adsorbent for the 2,4-Dichlorophenoxyacetic acid (2,4-D) herbicide removal from aqueous solutions. The obtained adsorbent was studied using infrared spectroscopy, scanning electron microscopy and Raman spectroscopy. The presence of graphene in the spray-dried powder was confirmed. The adsorption removal of 2,4-D using the obtained material was performed at an ambient temperature by varying the process parameters such as pH and adsorption time. The adsorption of 2,4-D was a monolayer chemisorption according to the Langmuir isotherm pattern and a pseudo-second-order kinetic model. The maximum Langmuir adsorption capacity of the monolayer was 35.181 mg/g. The results show that the Al2O3-0.25%vol. GO powder obtained by spray drying is suitable for the production of adsorbents for toxic herbicides.

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Does exposure to environmental 2,4-dichlorophenoxyacetic acid concentrations increase mortality rate in animals? A meta-analytic review

Cited by 18 publications

References 74 publications

PCBs, PCNs, and PCDD/Fs in Soil around an Industrial Park in Northwest China: Levels, Source Apportionment, and Human Health Risk

PCBs, PCNs, and PCDD/Fs in Soil around an Industrial Park in Northwest China: Levels, Source Apportionment, and Human Health Risk

Dinitroaniline herbicides: a comprehensive review of toxicity and side effects on animal non-target organisms

Removal of 2,4-Dichlorophenoxyacetic Acid from Aqueous Solutions Using Al2O3/Graphene Oxide Granules Prepared by Spray-Drying Method

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