Does Exposure of Lead and Cadmium Affect the Endometriosis?

Kim, Mingi; Min, Young-Sun; Ahn, Yeon-Soon

doi:10.3390/ijerph18179077

Cited by 8 publications

(23 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven epidemiological studies have indicated associations between the exposure to selected metals and endometriosis (Zhang et al 2021 ; Lai et al 2017 ; Tanrikut et al 2014 ; Pollack et al 2013 ; Kim et al 2021 ; Silva et al 2013 , Yılmaz et al 2020 ). Studies mostly assess cadmium and lead exposure (six of them) (Zhang et al 2021 ; Lai et al 2017 ; Tanrikut et al 2014 ; Pollack et al 2013 ; Kim et al 2021 ; Silva et al 2013 ), copper (three of them) (Lai et al 2017 , Pollack et al 2013 , Yılmaz et al 2020 ), and mercury (four of them) (Zhang et al 2021 ; Lai et al 2017 ; Tanrikut et al 2014 ; Pollack et al 2013 ) exposure. Other metals such as nickel (Silva et al 2013 ; Yılmaz et al 2020 ), zinc (Lai et al 2017 ; Yılmaz et al 2020 ), manganese, iron (Lai et al 2017 ), aluminum (Yılmaz et al 2020 ), and chromium (Lai et al 2017 ; Pollack et al 2013 ) also have been studied in relation to endometriosis.…”

Section: Resultsmentioning

confidence: 99%

An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies

Szczęsna

Wieczorek

Jurewicz

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Widespread exposure to persistent pollutants can disrupt the bodies’ natural endocrine functions and contribute to reproductive diseases like endometriosis. In this review, we focus at the relationship between endocrine-disrupting chemicals (EDCs), including metals and trace elements, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), poly-brominated diphenyl ethers (PBDEs), polychlorinated dibenzodioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and per- and polyfluoroalkyl substances (PFAS) exposure and risk of endometriosis. Relevant studies from the last 10 years by November 2022 were identified by searching Pubmed, Web of Science, and Scopus. The cohort and case–control studies that reported effect size with 95% confidence intervals (CIs) of EDC exposure and endometriosis were selected. Twenty three articles examining the relationship between endometriosis and exposure to persistent EDCs were considered. Most of the studies indicated association with exposure to persistent chemicals and development of endometriosis. The consistent results were found in case of lead, PCB-28, PCB-138, PCB-153, PCB-180, PCB-201, 1,2,3,7,8 — PeCDD, 2,3,4,7,8 — PeCDF and all described OCPs, showing the increased risk of endometriosis. These results support that exposure to certain EDCs, including OCPs, PCBs, PBBs, PBDEs, PFAS, and lead increase the risk of endometriosis.

show abstract

Section: Resultsmentioning

confidence: 99%

An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies

Szczęsna

Wieczorek

Jurewicz

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…Out of 30 eligible articles included in the present systematic review, 16 articles focused on clinical studies investigating IVF outcomes (Table 1) (16, 21-35) while 14 articles focused on clinical studies that investigated reproductive concerns (Table 2) (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies investigated the role of heavy metals and metalloids in infertility (41,47). The study by Tanrikut et al (40) revealed that Cd was found in 91% of women diagnosed with unexplained infertility against 34% of fertile women. Pb was found in 15% of women diagnosed with unexplained infertility and 3% of fertile women.…”

Section: Heavy Metals/metalloids and Reproductive Concernsmentioning

confidence: 99%

“…In these 8 studies, Pb and Cd stand out as major reoccurring metals in women with history of spontaneous abortion. Two studies investigated the relationship between heavy metals/metalloids and endometriosis (39,40). Zhang et al (38) found no association between Hg and endometriosis (39) while Kim et al (39) observed an increase in the standard admission rate (SAR) (1.24 (95% CI: 1.03-1.48) and admission odds ratio (OR) [1.44 (95% CI: 1.11-1.85)] for endometriosis in Pb exposed workers compared with that of the general population (40).…”

Section: Heavy Metals/metalloids and Reproductive Concernsmentioning

confidence: 99%

See 1 more Smart Citation

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

Obasi

Frazzoli

Orisakwe

2022

Front. Reprod. Health

View full text Add to dashboard Cite

Exposures to heavy metals and metalloids have been associated with decreased fecundity and fertility in couples conceiving via assisted reproduction. Heavy metals and metalloids can alter the homeostasis of critical hormones controlling sexual maturation by binding to critical hormones and receptors. This may disrupt the time course of sexual maturation directly or indirectly affecting reproductive competence in males and females. The present review aims to provide a summarized overview of associations between heavy metal exposure, reproductive concerns, and IVF outcomes. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in Google Scholar, Scopus, EMBASE and PubMed databases. Initial search produced 1,351 articles from which 30 articles were eligible to be included in the systematic review. From our results, 16 articles reported associations between selected heavy metals and IVF outcomes, while 14 articles summarized the role of heavy metals in reproductive concerns. For the studies on IVF outcomes, different human samples were examined for heavy metals. Heavy metals and metalloids (Pb, Hg, Cd, Cr, Mn, As) correlated negatively with oocyte fertilization/pregnancy rates in hair, follicular fluid, serum, urine and seminal plasma samples, while Cd and Hg in whole blood samples showed no associations. For the studies on reproductive concerns, high levels of heavy metals/metalloids were implicated in the following conditions: infertility (Cd, Pb, Ba, U), spontaneous abortion/miscarriage (Pb, Cd, Sb), congenital heart disease (Al, Mg, Cd), PCOS (As, Cd, Hg, Pb), endometriosis (Pb) and uterine leiomyomata (Hg). Taken together, the results of our study suggest that the impact of heavy metals and metalloids exposure on reproductive health may contribute to the failure rates of in vitro fertilization.

show abstract

“…A study performed by Kim proved that co-exposure to cadmium as well as lead was associated with a higher incidence of hospitalization in patients suffering from endometriosis [ 90 ].…”

Section: Trace Elements and Endometriosismentioning

confidence: 99%

Brief Review of Endometriosis and the Role of Trace Elements

Osuchowska-Grochowska

Blicharska

Gogacz

et al. 2021

IJMS

View full text Add to dashboard Cite

Endometriosis is a chronic, estrogen-dependent, inflammatory condition that is defined as the presence of endometrial glands and stroma outside the uterine cavity. Despite the progress in research into the mechanisms leading to the development of endometriosis, its cause has not yet been established. It seems to be possible that the formation of oxidative stress may be one of the main causes of the development of endometriosis. There is much research that studies the potential role of trace elements in the appearance of endometrial-like lesions. Most studies focus on assessing the content of selected trace elements in the blood, urine, or peritoneal fluid in women with endometriosis. Meanwhile, little is known about the content of these elements in endometrial-like implants, which may be helpful in developing the theory of endometriosis. Investigations that are more comprehensive are needed to confirm a hypothesis that some trace elements play a role in the pathomechanism of endometriosis.

show abstract

Does Exposure of Lead and Cadmium Affect the Endometriosis?

Cited by 8 publications

References 28 publications

An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies

An exposure to endocrine active persistent pollutants and endometriosis — a review of current epidemiological studies

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

Brief Review of Endometriosis and the Role of Trace Elements

Contact Info

Product

Resources

About