Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study

Paradisi, Roberto; Ferrini, Giulia; Matteucci, Carlotta; Facchini, Chiara; Zannoni, Letizia; Seracchioli, Renato

doi:10.1016/j.tjog.2017.04.020

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…It might reflect the changes in coagulation status that has been described in patients with endometriosis [42]. Recent evidences in fact have reported higher prevalence of trombophilic disorders in endometriosis patients [43]. The lower levels of prothrombin in urines of endometriosis patients might reflect this specific coagulation status.…”

Section: Discussionmentioning

confidence: 89%

Identification of Novel Putative Urinary Markers of Endometriosis by High-Resolution Quantitative Proteomics

Grande¹,

Milardi

Vincenzoni

et al. 2020

BJSTR

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Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. Endometriosis affects 7-10% of women of reproductive age, 60% of women with pelvic pain and up to 50% of women with infertility [1]. The spectrum of symptoms includes dysmenorrhea, dyspareunia, chronic pelvic pain, dyschezia, dysuria. However, recognition and conclusive diagnosis is only made on the average approximately 9 years following the beginning of the disease [2]. Early detection of the disease would allow patients earlier options for treatment, i.e. a sooner medical or surgical treatment and follow-up. The current gold standard for the diagnosis of the disease requests laparoscopic evaluation and biopsy of the visualized lesions [3]. Although laparoscopy is a minimally invasive procedure, it requires general anesthesia, developed surgical skills and it has a high procedural cost. In addition, laparoscopy is associated with a, although rare, risk of potential intra-operative or post-operative complications [4,5]. The

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Section: Discussionmentioning

confidence: 89%

Identification of Novel Putative Urinary Markers of Endometriosis by High-Resolution Quantitative Proteomics

Grande¹,

Milardi

Vincenzoni

et al. 2020

BJSTR

View full text Add to dashboard Cite

show abstract

“…In a small study, screening for thrombophilia showed that the prevalence of prothrombin G20210A mutation and hyperhomocysteinemia in patients with endometriosis was not different from that of the general population and prevalence of factor V-Leiden mutation, was found with a lower prevalence 14 . In another study in which emphasis was given in fibrinolysis and plasminogen activator inhibitor-1 (PAI-1) gene, endometriosis was more likely in patients with 4G/5G or 4G/4G which are associated with hypofibrinolysis compared with 5G/5G PAI-1 genotype 15 .Nevertheless, the existence of 4G allele alone does not represent an independent high risk factor of thromboembolic disease.…”

Section: Genes Of Thrombotic Riskmentioning

confidence: 93%

Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

Kanellopoulou¹

2020

HJOG

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Endometriosis is a chronic inflammatory disease of women of reproductive age that is defined by the presence of ectopic endometrium. The pathophysiology of the disease is poorly understood, however platelet activation play a crucial role in initiation of inflammation and fibrinogenesis, which in term further activate the coagulation cascade. The relationship between inflammation and coagulation motivated researchers to study whether patients are in a hypercoagulable state and if endometriosis represent an independent risk factor for venous thromboembolism or cardiovascular risk. This review article focuses on the role of coagulation, the risk of thrombosis and a possible beneficial effect of antithrombotic-treatment.

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Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study

Abstract: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.

Cited by 2 publications

References 18 publications

Identification of Novel Putative Urinary Markers of Endometriosis by High-Resolution Quantitative Proteomics

Identification of Novel Putative Urinary Markers of Endometriosis by High-Resolution Quantitative Proteomics

Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

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