Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

Bizjak, Daniel Alexander; Tomschi, Fabian; Bales, Gunnar; Nader, Élie; Romana, Marc; Connes, Philippe; Bloch, Wilhelm; Grau, Marijke

doi:10.1016/j.jshs.2019.02.002

Cited by 27 publications

(25 citation statements)

References 37 publications

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“…In support, RBC deformability decreased after a 30 min intense cycling test, pointing to an accumulation of damage during the bout. Indeed, training results in increased RBC turnover [ 72 ] and a younger overall RBC population [ 73 ]. Furthermore, RBCs from endurance athletes tend to be more deformable [ 74 ], which suggests that these cells have more “youthful” characteristics.…”

Section: Discussionmentioning

confidence: 99%

Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling

Nemkov

Skinner

Nader

et al. 2021

IJMS

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Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward increased generation of microparticles after the test. Meanwhile, metabolomics and lipidomics highlighted oxidative stress and activation of membrane lipid remodeling mechanisms in order to cope with altered properties of circulation resulting from physical exertion during the cycling test. Of note, intermediates from coenzyme A (CoA) synthesis for conjugation to fatty acyl chains, in parallel with reversible conversion of carnitine and acylcarnitines, emerged as metabolites that significantly correlate with RBC deformability and the generation of microparticles during exercise. Taken together, we propose that RBC membrane remodeling and repair plays an active role in the physiologic response to exercise by altering RBC properties.

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Section: Discussionmentioning

confidence: 99%

Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling

Nemkov

Skinner

Nader

et al. 2021

IJMS

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“…While these matrices possess unique advantages in their own right, such as the ability to measure freely circulating metabolites between tissues as is the case with plasma, they disregard the metabolism of circulating blood cells by nature of their collection methods. As appreciation is growing with respect to blood cell adaptations to exercise (Bizjak et al, 2019;de Oliveira Ottone et al, 2019;Estruel-Amades et al, 2019;Shi et al, 2019;Uchida et al, 2019), whole blood analysis enables a more complete representation of physiology. Furthermore, this sample collection is less labor intensive than serum or plasma isolation.…”

Section: Discussionmentioning

confidence: 99%

“…Considering that glutathione and PPP intermediates are intracellular metabolites, it is likely that the major contributors to these pools in whole blood are red blood cells (RBCs), by far the most abundant cell in both circulation and the human body (Sender et al, 2016). While exercise promotes erythropoiesis due to increased oxygen demand and need to replenish RBC populations in response to elevated hemolysis (reviewed in Mairbäurl, 2013) effects on RBC circulatory lifespan have only recently been appreciated (Bizjak et al, 2019). One of the hallmarks of RBC aging both in circulation (Lutz and Bogdanova, 2013) and in the blood bank (Nemkov et al, 2015;Yoshida et al, 2019) an environment that accelerates RBC aging (D'Alessandro et al, 2015) is the accumulation of oxidative stress markers including oxidized glutathione and allantoate.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics of Endurance Capacity in World Tour Professional Cyclists

et al. 2020

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“…RBC-NOS generated NO was shown to increase S-nitrosylation of the cytoskeletal proteins α- and β-spectrin which was associated to increased RBC deformability (Grau et al, 2013). These reaction routes are well described for mechanical stimulation (Ulker et al, 2009, 2010; Kuck et al, 2019), endurance sports (Suhr et al, 2012; Koliamitra et al, 2017; Tomschi et al, 2018b; Bizjak et al, 2019), but also other types of sport were shown to affect RBC-NOS/NO pathway and RBC deformability (Bizjak et al, 2018). The impact of WB-EMS stimuli on the RBC-NOS/NO signaling pathway has been first shown by Filipovic et al (2015) suggesting that WB-EMS affects RBC deformability with acute changes being explained by increased RBC-NOS activation while chronic changes in RBC deformability did not involve RBC-NOS activation.…”

Section: Discussionmentioning

confidence: 88%

Influence of Whole-Body Electrostimulation on the Deformability of Density-Separated Red Blood Cells in Soccer Players

et al. 2019

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Red blood cell nitric oxide synthase (RBC-NOS) dependent NO production positively affects RBC deformability which is known to improve oxygen supply to the working tissue. Whole-body electrostimulation (WB-EMS) has been shown to improve maximum strength, sprinting and jumping performance, and to increase deformability in elite soccer players during the season. The aim of the present study was to investigate whether WB-EMS affects RBC turnover which might affect overall deformability of circulating RBC by rejuvenation of the RBC population and if this might be related to improved endurance capacity. Thirty male field soccer players were assigned in either a WB-EMS group (EG, n = 10), a training group (TG, n = 10), or a control group (CG, n = 10). EG performed 3 × 10 squat jumps superimposed with WB-EMS twice per week in concurrent to 2–4 soccer training sessions and one match per week. TG only performed 3 × 10 squat jumps without EMS in addition to their soccer routine and the CG only performed the usual soccer training and match per week. Subjects were tested before (Baseline) and in week 7 (wk-7), with blood sampling before (Pre), 15–30 min after (Post), and 24 h after (24 h post) the training. Endurance capacity was determined before and directly after the training period. The key findings of the investigation indicate an increase in young RBC in the EG group along with improved overall RBC deformability, represented by decreased SS1/2:EImax Ratio. Analysis of the different RBC subfractions revealed improved RBC deformability of old RBC during study period. This improvement was not only observed in the EG but also in TG and CG. Changes in RBC deformability were not associated to altered RBC-NOS/NO signaling pathway. Endurance capacity remained unchanged during study period. In summary, the effect of WB-EMS on RBC physiology seems to be rather low and results are only in part comparable to previous findings. According to the lower training volume of the present study it can be speculated that the soccer specific training load in addition to the WB-EMS was too low to induce changes in RBC physiology.

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Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

Cited by 27 publications

References 37 publications

Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling

Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling

Metabolomics of Endurance Capacity in World Tour Professional Cyclists

Influence of Whole-Body Electrostimulation on the Deformability of Density-Separated Red Blood Cells in Soccer Players

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