Does endometrial injury improve implantation of frozen–thawed embryos?

Abstract

Based on the results of this pilot study, EI in the luteal phase of the cycle preceding the frozen embryo transfer cycle does not appear to significantly improve implantation or clinical pregnancy rates.

The effect of endometrial scratch injury on pregnancy outcome in women with previous intrauterine insemination failure: A randomized clinical trial

“…Elsewhere, El‐Khayat et al evaluated the effect of ESI on office hysteroscopy in the cycle preceding IUI, and observed no evidence of significant improvement in the clinical pregnancy rate in comparison with the control group . In a similar way, Baum et al and Dunne and Taylor found no difference in pregnancy outcome between the study groups (ESI vs control) in the IVF and frozen embryo cycles, respectively …”

Effect of endometrial injury during menstruation on clinical outcomes in frozen–thawed embryo transfer cycles: A randomized control trial

“…It has been known that EI can remove irregular hyperplasia of endometrial tissue, promote epithelial cells, stromal cells proliferation and differentiation, and enrich the endometrial blood flow . Up to now, there were six trials focusing on the effect of EI in luteal phase prior to frozen–thawed ET cycle . The results of these trials seem contradictive to each other and no firm conclusion can be made whether performing EI in luteal phase of the subsequent frozen–thawed ET cycle is beneficial.…”

“…8 Up to now, there were six trials focusing on the effect of EI in luteal phase prior to frozen-thawed ET cycle. [17][18][19][28][29][30] The results of these trials seem contradictive to each other and no firm conclusion can be made whether performing EI in luteal phase of the subsequent frozenthawed ET cycle is beneficial. Among the studies, only one study focused on the effect of EI in luteal phase before a frozen-thawed ET cycle on live birth rate.…”

“…The effect of EI before using frozen–thawed ET cycles has not been well explored. With limited proceeding studies, it seems like EI did not have any beneficial effects on an unselected group of women undergoing frozen–thawed ET . However, Kanazawa et al .…”

“…With limited proceeding studies, it seems like EI did not have any beneficial effects on an unselected group of women undergoing frozen-thawed ET. 18,19 However, Kanazawa et al suggested that EI had a positive effect on pregnancy rate prior to frozen-thawed ET cycles in patients suffered repeated implantation failures (RIF). 20 Current studies in the field mainly focused on performing EI in luteal phase prior to frozen-thawed ET.…”