Does endocan level increase in women with polycystic ovary syndrome? A case — control study

Delibaş, İlhan Bahri; Yapça, Ömer Erkan; Laloğlu, Esra

doi:10.5603/gp.a2018.0085

Cited by 6 publications

(12 citation statements)

References 32 publications

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“…Our findings are opposite to previous reports of the inverse association between endocan level and traditional obesity indexes, BMI and/or WC (12)(13)(14)(15). The possible discrepancies in such results may be explained with the age and sex differences, as well as different ethnic groups that previous studies included.…”

Section: Discussioncontrasting

confidence: 99%

“…However, there are discordant results about relationship between serum endocan level and obesity. Namely, some studies reported lower endocan levels in the obese state (11), as well as an inverse association between circulating level of endocan and the most commonly used obesity indices, such as body mass index (BMI) (12)(13)(14) and waist circumference (WC) (15) in different population groups. Contrary to this, the others showed the positive association between circulating endocan level and mentioned obesity indices, BMI (16 -18) and WC (18).…”

Section: Introductionmentioning

confidence: 99%

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Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population

Klisić¹,

Kavarić²,

Spasojević‐Kalimanovska³

et al. 2021

J Med Biochemistry

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Background and Aim: Association between endocan and non-traditional anthropometric indices, as distinct cardiovascular disease risk factors, has not been examined in previous studies. Endocan is a novel inflammation biomarker with its higher levels involved in cardiometabolic diseases development. Taking into consideration that obesity is an independent risk factor for many cardiometabolic diseases, we aimed to explore the relationship between endocan levels and novel anthropometric indices [i.e., body adiposity index (BAI), cardiometabolic index (CMI), a body shape index, body roundness index, conicity index, lipid accumulation product index and visceral adiposity index] and traditional ones [i.e., waist circumference, hip circumference, body mass index, waist-to-height ratio and waist-to-hip ratio] in adult population.Methods: A total of 177 participants were included. Anthropometric indices and biochemical parametres were measured. Results: Univariate regression analysis demonstrated positive correlations of endocan and almost all anthropometric data. To explore independent associations of endocan and anthropometric parameters, the Model which fulfilled criteria for ordinal regression testing was created. Adjusted odds for BAI given in the Model (OR=1.120, 95% CI 1.036-1.212, P=0.004), demonstrated that a rise in BAI by 1 unit increased the probability of higher endocan concentration by 12%. As well, a rise in CMI for 1 unit, increased probability for higher endocan levels for 2.6 times (OR=2.599, 95% CI 1.006-6.712, P=0.049). A total of 20.1% of variation in endocan levels could be explained by this Model.Conclusion: Non-traditional obesity indices, BAI and CMI independently correlated with higher serum endocan levels in adult population.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population

Klisić¹,

Kavarić²,

Spasojević‐Kalimanovska³

et al. 2021

J Med Biochemistry

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show abstract

“…However, the existing data regarding the association between endocan and obesity are controversial. While some studies have shown higher endocan levels in obesity [ 6 ] and a positive correlation between anthropometric measurements of both overall obesity (i.e., body mass index (BMI)) [ 10 , 14 , 15 ] and abdominal obesity (i.e., waist circumference (WC)) [ 10 ], others have reported the opposite, i.e., lower endocan levels in obesity [ 16 ] and a negative association with the anthropometric indices [ 17 , 18 , 19 ]. Such controversies might be attributed to the different ethnic groups studied, the phenotypes of adiposity, the duration and extent of obesity, and the sample size of the studied population.…”

Section: Endocan and Obesitymentioning

confidence: 99%

The Role of Endocan in Cardiometabolic Disorders

Klisić

Patoulias

2023

Metabolites

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Discovered two decades ago, endocan still represents an intriguing biomarker related to inflammation. Endocan is a soluble dermatan sulphate proteoglycan secreted by endothelial cells. Its expression is observed in tissues related to the enhanced proliferation, especially hepatocytes, lungs, kidneys, etc. Endocan has been investigated in many cardiometabolic disorders that are tightly connected with inflammation, such as type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, non-alcoholic fatty liver disease, etc. In this narrative, comprehensive review of the currently available literature, special attention will be paid to the role of endocan in the broad spectrum of cardiometabolic disorders. Since endocan has emerged as a novel endothelial dysfunction marker, the discovery of potential therapeutic strategies for patients with certain cardiometabolic risk factors would be of great importance to delay or even prevent the onset and progression of related complications, mainly cardiovascular.

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“…Polycystic ovary syndrome (PCOS) is an endocrinological disease that aff ects 6-18% of women of reproductive age and has a wide range of metabolic eff ects. 1,2 It is the most common cause of infertility in women. 3 Th e main clinical features of PCOS are ovulatory dysfunction and hyperandrogenism, and these fi ndings may persist throughout the reproductive period.…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, endocan levels in PCOS, as in other chronic diseases, were found to be higher than healthy control groups. 1,13,16,[18][19][20] Th e aim of this study is to compare the endocan level in PCOS patients with the healthy control group and to show the relationship between some cardiovascular risk indicators accompanying PCOS and endocan level.…”

Section: Introductionmentioning

confidence: 99%

Poli̇ki̇sti̇k Over Sendromunda (Pkos) Endotelyal Di̇sfonksi̇yonun Erken Serum Beli̇rteci̇: Endocan

Apaydın¹,

Demirci²,

Çakal³

2021

Sakarya Medical Journal

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Objective Polycystic ovary syndrome (PCOS) is a common endocrinological disease in women of reproductive age and has a wide range of metabolic effects. Chronic low-grade inflammation and endothelial dysfunction plays a key role in the pathogenesis of PCOS and they are associated with an increased risk of cardiovascular disease. Endocan, is an inflammatory marker showing endothelial dysfunction. The aim of our study, to compare serum endocan levels in PCOS and healthy control groups and to determine the relationship between some cardiovascular risk factors and serum endocan levels. Materials and Methods This case-control study included 52 PCOS patients and 59 age-matched healthy controls. Patients were diagnosed as PCOS based on 2003 Rotterdam criteria. Demographic data, history of menstrual irregularity and infertility, polycystic ovary appearance in ultrasonography and hirsutism status were recorded. Endocan levels of PCOS patients and controls were compared. Data analysis was performed by using SPSS-22 for Windows (Statistical Package for Social Science, SPSS Inc. Chicago IL, USA®Z). Results The median (IQR) value of serum endocan level was 420.7 ng/L (355.2-570.3) in the PCOS group and 320.0 ng/L (219.9-455.9) in the control group (p=0.003). While there was no significant correlation between serum endocan and some cardiovascular risk factors such as waist circumference, hip circumference, BMI, LDL, triglyceride, systolic and diastolic arterial tension but a positive correlation was found between homeostatic model assessment insulin resistance (HOMA-IR) (r= 0.276, p= 0.003). Conclusion Serum endocan levels are higher in PCOS patients, in line with the literature. Endocan level shows a significant correlation with insulin resistance, one of the metabolic parameters. This may be a sign of early endothelial dysfunction in PCOS. Keywords endocan; endothelial dysfunction; polycystic ovary syndrome; inflammation Öz Amaç Polikistik over sendromu (PKOS), üreme çağındaki kadınlarda sık görülen endokrinolojik hastalıktır. PKOS'ta izlenen kronik düşük dereceli inflamasyon ve endotel disfonksiyon artmış kardiyovasküler hastalık riski ile ilişkilidir. Endocan, endotel disfonksiyonunu gösteren inflamatuar bir belirteçtir. Çalışmamızda PKOS ve sağlıklı kontrol grubunu serum endocan düzeyleri açısından karşılaştırmayı ve kardiyovasküler risk faktörleri ile serum endocan düzeyleri arasındaki ilişkiyi belirlemeyi amaçladık.

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Does endocan level increase in women with polycystic ovary syndrome? A case — control study

Cited by 6 publications

References 32 publications

Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population

Serum endocan levels in relation to traditional and non-traditional anthropometric indices in adult population

The Role of Endocan in Cardiometabolic Disorders

Poli̇ki̇sti̇k Over Sendromunda (Pkos) Endotelyal Di̇sfonksi̇yonun Erken Serum Beli̇rteci̇: Endocan

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