Does electrostatic charge affect powder aerosolisation?

Adi, Handoko; Kwok, Philip Chi Lip; Crapper, John; Young, Paul M.; Traini, Daniela; Chan, Hak‐Kim

doi:10.1002/jps.21996

Cited by 24 publications

(9 citation statements)

References 30 publications

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“…However, the surfaces of the resultant particles did not show the typical finger-like nano-scale crystals on SD or SFD pure mannitol particles [44,45]. Rather, the SD particles produced in the current study appeared to have a wrinkled coating while the SFD particles were composed of porous, folded sheets.…”

Section: Discussioncontrasting

confidence: 53%

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

Liang

Kwok

Chow

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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Nucleic acids have the potential to be used as therapies or vaccines for many different types of disease but delivery remains the most significant challenge to their clinical adoption. pH responsive peptides containing either histidine or derivatives of 2,3-diaminopropionic acid (Dap) can mediate effective DNA transfection in lung epithelial cells with the latter remaining effective even in the presence of lung surfactant containing bronchoalveolar fluid (BALF), making this class of peptides attractive candidates for delivering nucleic acids to lung tissues. To further assess the suitability of pH responsive peptides for pulmonary delivery by inhalation, dry powder formulations of pH responsive peptides and plasmid DNA, with mannitol as carrier, were produced by either spray drying (SD) or spray freeze drying (SFD). The properties of the two types of powders were characterised and compared using scanning electron microscopy (SEM), next generation impaction (NGI), gel retardation and in vitro transfection via a twin-stage impinger (TSI) following aerosolisation by a dry powder inhaler (Osmohaler™). Although the aerodynamic performance and transfection efficacy of both powders were good, the overall performance revealed SD powders to have a number of advantages over SFD powders and are the more effective formulation with potential for efficient nucleic acid delivery through inhalation.

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Section: Discussioncontrasting

confidence: 53%

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

Liang

Kwok

Chow

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…In contrast to this Adi et al (2010) came to the conclusion that the aerosolisation of a powder is not affected by electrostatic charge. They charged mannitol powder to different magnitudes of charge by tumbling it inside containers of different materials and then dispersed it from an Aerolizer s .…”

Section: Relative Humiditymentioning

confidence: 69%

The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders

Karner

Urbanetz

2011

Journal of Aerosol Science

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“…Since micron-sized material tends to self-agglomerate, to minimize variability in agglomerate size, mannitol was subjected to Turbula mixing (Bachofen AG Maschinenfabrik, Basel, Switzerland) in a cylindrical aluminium container (25 mm diameter×36 mm length) at 42 rpm for 15 min using conditions reported previously (24). After mixing, the primary agglomerates were passed through a nest of sieves (ISO 3310-1 test sieves, Endecotts Ltd., London, UK) to produce a 500 μm-800 μm sieve fraction.…”

Section: Preparation Of a Model Particulate Systemmentioning

confidence: 99%

Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems

et al. 2010

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Does electrostatic charge affect powder aerosolisation?

Cited by 24 publications

References 30 publications

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders

Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems

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