Does electrophoresis reliably screen for high serum lipoprotein Lp(a)?

Bruckert, Éric; Truffert, J; Gennes, J. L. De; Lagarde, Jean‐Pierre; Bernard, C.; Federspiel, Marie-Christine; Giral, Philippe; Dairou, F.

doi:10.1016/0009-8981(90)90147-k

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…[7][8][9] Plasma concentration of Lp(a) in humans ranges from Ͻ1 mg/dL to Ͼ100 mg/dL, with risk for cardiovascular disease associated with levels Ͼ25 to 30 mg/dL. 10,11 According to epidemiological studies, this threshold corresponds to the 75th 12 or 90th 13 percentile. Most initial studies designed to assess the correlation between the serum level of Lp(a) and restenosis after percutaneous transluminal coronary angioplasty (PTCA) have been limited to small groups of patients and have considered restenosis as a simple binary phenomenon, with incomplete angiographic follow-up; results of these studies are inconsistent.…”

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confidence: 99%

Plasma Lipoprotein(a) Is Not a Predictor for Restenosis After Elective High-Pressure Coronary Stenting

Ribichini¹,

Steffenino²,

Dellavalle³

et al. 1998

Circulation

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Background-Lipoprotein(a) is a risk factor for coronary artery disease. Although it has been implicated in restenosis after balloon angioplasty, its role in restenosis within coronary stents is unknown. The aim of the study was to assess the role of plasma lipoprotein(a) as a predictor for restenosis after elective coronary stenting. Methods and Results-Elective, high-pressure stenting of de novo lesions in native coronary arteries with Palmaz-Schatz stents was performed in 325 consecutive patients. Clinical, angiographic, and biochemical data were analyzed prospectively. Angiographic follow-up was performed at 6 months. Lipoprotein(a) levels were compared in patients with and without restenosis. Angiographic follow-up was obtained in 312 patients (96%); recurrence was observed in 67 patients (21.5%). No clinical or biochemical variable was associated with restenosis. Lipoprotein(a) level was 37.81Ϯ49.01 mg/dL (median, 22 mg/dL; range, 3 to 262 mg/dL) in restenotic patients and 36.95Ϯ40.65 mg/dL (median, 22 mg/dL; range, 0 to 244 mg/dL) in nonrestenotic patients (PϭNS). The correlations between percent diameter stenosis, minimum luminal diameter, and late loss at follow-up angiography and basal lipoprotein(a) plasma level after logarithmic transformation were 0.006, 0.002, and 0.0017, respectively. Multiple stents were associated with a higher incidence of restenosis (Pϭ0.006), but biochemical data in these patients were similar to those treated with single stents. Conclusions-The basal plasma level of lipoprotein(a) measured before the procedure is not a predictor for restenosis after elective high-pressure coronary stenting.

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