Does dyslipidemia worsen the hearing level in diabetics?

Pratap, Deepika; Rajeshwary, A.; Shastri, Usha; Goutham, MK; Raghav, Sharma

doi:10.1016/j.joto.2017.07.003

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…In previous studies [48,49], the association between SNHL, DM and cardiovascular disease has been established. However, the role of dyslipidemia and renal disease in SNHL remains limited or unclear [50,51]. Our results also demonstrated a signi cant relationship between SNHL and diabetes, particularly in individuals with mtDNA variants.. From a clinical perspective, there is a compelling rationale for actively monitoring the hearing of patients with MT-RNR1 gene mutations, especially those with comorbid conditions like diabetes.…”

Section: Discussionmentioning

confidence: 60%

Increased Risk of Hearing Loss Associated with MT-RNR1 Gene Mutations: A Real-World Investigation Among Han Taiwanese Population

Chen,

Hsieh,

Hsu

et al. 2024

Preprint

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Background: Previous studies have implicated inherited mutations in mitochondrial DNA (mtDNA) in sensorineural hearing loss. However, the definitive association between mitochondrial 12S rRNA (MT-RNR1) variants and hearing loss in the population has not been well established, particularly in Asia. The objective of this retrospective cohort study was to assess the association between MT-RNR1variants and the risk of hearing loss events in patients in Taiwan. Methods: We identified a cohort of 12,969 individuals, including 1,179 patients with MT-RNR1 variants, from the China Medical University Hospital Database between January 2003 and December 2020. These patients with MT-RNR1 variants were matched with a control group of 11,790 participants without such variants. The mean age of the mtDNA variants group is 32.4 years, with a standard deviation of 19.2 years. Results: The incidence density of hearing loss for the mutation group was 36.42 per 10,000 person-years (95% Confidence Interval [CI], 27.21-47.73), which was higher than the 23.77per 10,000 person-years (95% CI, 21.32-26.42) in the wild-type group (p<0.005). Additionally, diabetes mellitus was associated with an increased risk of developing sensorineural hearing loss in individuals with MT-RNR1 variants (adjusted hazard ratio=1.76 [95% CI, 1.00-3.09], p< 0.05). Conclusion: This study emphasizes the elevated risk of hearing loss events in patients with MT-RNR1 variants, especially those with co-existing disease. The findings highlight the necessity for strategies to prevent hearing loss events in this high-risk group, emphasizing early intervention and consideration of associated complications.

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Section: Discussionmentioning

confidence: 60%

Increased Risk of Hearing Loss Associated with MT-RNR1 Gene Mutations: A Real-World Investigation Among Han Taiwanese Population

Chen,

Hsieh,

Hsu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In previous studies [ 48 , 49 ], the association between SNHL, diabetes mellitus and cardiovascular disease has been established. However, the role of dyslipidemia and renal disease in SNHL remains limited or unclear [ 50 , 51 ]. Our results also demonstrated a significant relationship between SNHL and diabetes, particularly in individuals with mtDNA variants.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of hearing loss associated with MT-RNR1 gene mutations: a real-world investigation among Han Taiwanese Population

Chen,

Hsieh,

Hsu

et al. 2024

BMC Med Genomics

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Background Previous studies have implicated inherited mutations in mitochondrial DNA (mtDNA) in sensorineural hearing loss (SNHL). However, the definitive association between mitochondrial 12S rRNA (MT-RNR1) variants and hearing loss in the population has not been well established, particularly in Asia. The objective of this retrospective cohort study was to assess the association between MT-RNR1 variants and the risk of SNHL in patients in Taiwan. Methods The cohort included 306,068 participants from Taiwan between January 2003 and December 2020. Participants were classified based on genetic variants, particularly mitochondrial mutations (rs267606618, rs267606619, rs267606617). MT-RNR1 variant cases were matched 1:10 with non-mutant patients by age, gender, and visit year, excluding those with pre-existing hearing loss. The primary endpoint was SNHL, identified using specific ICD-TM codes with a 90% positive predictive value. Medication exposure history was determined via self-report or electronic medical records in the hospital. Cox proportional hazard regression models were used to assess the association between MT-RNR1 variants and hearing loss, adjusting for various covariates. Kaplan-Meier survival curves and log-rank tests compared hearing loss incidence between groups. Results The mean age of the mtDNA variants group is 32.4 years, with a standard deviation of 19.2 years. The incidence density of hearing loss for the mutation group was 36.42 per 10,000 person-years (95% Confidence Interval [CI], 27.21–47.73), which was higher than the 23.77per 10,000 person-years (95% CI, 21.32–26.42) in the wild-type group (p = 0.0036). Additionally, diabetes mellitus was associated with an increased risk of developing SNHL in individuals with MT-RNR1 variants (adjusted hazard ratio = 1.76 [95% CI, 1.00-3.09], p < 0.05). Conclusion This study highlights the increased risk of hearing loss in patients carrying MT-RNR1 variants, particularly those with diabetes mellitus. Future research that integrates genetic and clinical data is crucial for developing more precise interventions to monitor and treat hearing loss in this vulnerable population.

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“…b) Inner ear is an end organ and the blood supply of stria vascularis and hair cells is highly susceptible to vascular events. Hyperlipidemia leads to deposition of lipids in end arteries, thereby causing narrowing, resulting in compromised blood supply causing chronic hypoxia that disturbs cochlear metabolism [21].…”

Section: Discussionmentioning

confidence: 99%

Presbycusis and hyperlipidemia: Is there any link?

Azeez¹,

Ansary²,

Yasin³

2020

MMJ

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"Age related hearing loss is one of the most common chronic health conditions affecting the elderly people. With aging, risk of Presbycusis and hyperlipidemia increases. Although most studies do reach some sort of agreement, the evidence supporting a relationship between presbycusis and hyperlipidemia remains questionable. The objective of this study is to determine the association between age related hearing loss and hyperlipidemia and assess the severity of hearing loss in hyperlipidemic patients. This cross sectional analytic study was carried out at ENT Out Patient Clinic at Al Sader teaching Hospital from March 2019 to December 2019. A cross‑sectional study on 52 patients with Hyperlipidemia and 42 non Hyperlipidemic patients was carried out during March 2019 to December 2019. All patients were evaluated for hearing loss by subjecting to pure tone audiometry, blood investigations were done in form of lipid profile, blood sugars, thyroid function test, blood urea and serum creatinine levels. Group A consisted of 22 (42.3%) males and 30 (57.7%) female while group B consisted of 23 (54.8%) male and 19 (45.2%) female individuals. Audiological assessment by PTA was show that the prevalence of presbycusis among hyperlipidemic group more than non hyperlipidemic with significant statistical difference (P value <0.05). Prevalence was 76.9%. In conclusion; there is statistically significant association between presbycusis and hyperlipidemia especially those with hyercholestrolemia.

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Does dyslipidemia worsen the hearing level in diabetics?

Cited by 6 publications

References 20 publications

Increased Risk of Hearing Loss Associated with MT-RNR1 Gene Mutations: A Real-World Investigation Among Han Taiwanese Population

Increased Risk of Hearing Loss Associated with MT-RNR1 Gene Mutations: A Real-World Investigation Among Han Taiwanese Population

Increased risk of hearing loss associated with MT-RNR1 gene mutations: a real-world investigation among Han Taiwanese Population

Presbycusis and hyperlipidemia: Is there any link?

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