Does digoxin sensitize left ventricular mechanoreceptors?

Vogt, A.; Bretschneider, S; Ri, H. Dal; Schmidt, Gerhard; Kreuzer, H

doi:10.1007/bf02005183

Cited by 3 publications

References 17 publications

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Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Lajoie

Calderone

Béliveau

2004

Pflugers Arch - Eur J Physiol

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Exercise training could potentially exert beneficial effects on the signaling events associated with cardiac cell apoptosis. Spontaneously hypertensive rats (SHR) were trained 5 days/week on a treadmill (18 m/min for 120 min/day) between the ages of 4 weeks and 1 week, corresponding to the hypertensive accelerating phase. The effect of exercise training on the expression of anti-apoptotic proteins HSP-72, Bcl-2 and protein kinase B (PKB), and the apoptotic proteins Bax and glycogen synthase kinase-3 (GSK-3) was examined. Exercise had a significant acute lowering effect on blood pressure, but this decrease did not attenuate the progressive increase in blood pressure. In the left ventricles of exercised SHR, PKB phosphorylation of both Ser473 and Thr308 residues was significantly increased by 166% and 120%, respectively, compared to sedentary SHR. PKB phosphorylation significantly correlated with GSK-3beta phosphorylation. HSP-72 and Bcl-2 protein expression were increased in the left ventricle of exercised SHR, and associated with the concomitant increased expression of the protein Bax. Thus, the Bcl-2/Bax ratio was not changed by exercise training, suggesting that the anti-apoptotic mechanism was effective in compensating the increase in the expression of the pro-apoptotic protein Bax in the myocardium of the SHR.

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Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Lajoie

Calderone

Béliveau

2004

Pflugers Arch - Eur J Physiol

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Digitalis: Its Mode of Action, Receptor, and Structure–Activity Relationships

Thomas

Gray

Andrews

1990

Advances in Drug Research

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Effects of exercise training on cardiac function, gene expression, and apoptosis in rats

Jin¹,

Yang²,

Li³

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

112

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This study determined the effects of exercise training on cardiac function, gene expression, and apoptosis. Rats exposed to a regimen of treadmill exercise for 13 wk had a significant increase in cardiac index and stroke volume index and a concomitant decrease in systemic vascular resistance compared with both age-matched and body weight-matched sedentary controls in the conscious state at rest. In exercise-trained animals, there was no change in the expression of several marker genes known to be associated with pathological cardiac adaptation, including atrial natriuretic factor, beta-myosin heavy chain, alpha-skeletal and smooth muscle actins, and collagens I and III. Exercise training, however, produced a significant induction of alpha-myosin heavy chain, which was not observed in rats with myocardial infarction. No histological features of cardiac apoptosis were observed in the treadmill-trained rats. In contrast, apoptotic myocytes were detected in animals with myocardial infarction. In summary, exercise training improves cardiac function without evidence of cardiac apoptosis and produces a pattern of cardiac gene expression distinct from pathological cardiac adaptation.

show abstract

Does digoxin sensitize left ventricular mechanoreceptors?

Cited by 3 publications

References 17 publications

Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats

Digitalis: Its Mode of Action, Receptor, and Structure–Activity Relationships

Effects of exercise training on cardiac function, gene expression, and apoptosis in rats

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