Does diclofenac act like a photosynthetic herbicide on green algae? Chlamydomonas reinhardtii synchronous culture-based study with atrazine as reference

Majewska, Maria Dorota; Harshkova, Darya; Pokora, Wojciech; Baścik-Remisiewicz, Agnieszka; Tułodziecki, Szymon; Aksmann, Anna

doi:10.1016/j.ecoenv.2020.111630

Cited by 22 publications

(5 citation statements)

References 72 publications

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“…The use of synchronous cell cultures allowed us to verify the hypothesis that one of the causes of DCF phytotoxicity was the disorder of cell cycle progression, and extend the findings of our previous works [9,35,36]. The anti-proliferative effect of DCF, reported in the literature for mammalian cells [47], also appeared to be valid for C. reinhardtii cells.…”

Section: Discussionsupporting

confidence: 75%

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Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii

Harshkova

Liakh

Bialevich

et al. 2021

Cells

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The aim of the study was to verify the hypothesis that a potential cause of the phytotoxicity of diclofenac (DCF, a non-steroidal anti-inflammatory drug) is an effect of cell cycle progression. This research was conducted using synchronous cultures of a model organism, green alga Chlamydomonas reinhardtii. The project examined DCF effects on selected parameters that characterize cell cycle progression, such as cell size, attainment of commitment points, DNA replication, number of nuclei formed during cells division and morphology of cells in consecutive stages of the cell cycle, together with the physiological and biochemical parameters of algae cells at different stages. We demonstrated that individual cell growth remained unaffected, whereas cell division was delayed in the DCF-treated groups grown in continuous light conditions, and the number of daughter cells from a single cell decreased. Thus, the cell cycle progression is a target affected by DCF, which has a similar anti-proliferative effect on mammalian cells.

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Section: Discussionsupporting

confidence: 75%

“…Data described in our previous studies showed that in asynchronous cultures of C. reinhardtii, DCF caused oxidative stress and affected photosynthesis [9,35,36]. However, it was not clear what was its effect would be on growth and cell reproduction (cell cycle) and if they were both affected similarly or not.…”

Section: Discussionmentioning

confidence: 92%

Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii

Harshkova

Liakh

Bialevich

et al. 2021

Cells

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“…On the other hand, negative control (NC) having solution with DFS (100 mg L −1 ) showed devoid growth. This is attributed to the fact that a high concentration of DFS was toxic which inhibits the growth of microalgae, eventually leading to non‐survivalship of microalgae [51,52] . Moreover, growth parameters in PC 2 were also hand in hand with PC 1 suggesting that NGS was non‐toxic to microalgal cells.…”

Section: Resultsmentioning

confidence: 99%

Nitrogen‐Doped Graphene Nanosheets for Sustainable Removal of Pharmaceutical Contaminants from Water: Kinetics and ANFIS Modeling

et al. 2023

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In this work, nitrogen‐doped graphene nanosheets (NGS) were synthesized to remove diclofenac sodium (DFS) from water. The NGS exhibited 99.8 % removal efficiency, adsorption capacity of 278 mg g−1 for DFS within 30 min, and excellent reusability up to 5 cycles of adsorption. The experimental data fit well with pseudo‐second order kinetic model and Langmuir isotherm model. X‐ray photoelectron spectroscopy (XPS) and FTIR studies revealed that the carboxylic group, triazine group, graphitic‐N, and pyridinic‐N groups were involved in the adsorption of DFS. The adaptive neuro‐fuzzy inference system (ANFIS) was modeled for accurate prediction of optimizing parameters for the maximum adsorptive removal (%) of DFS by NGS. A subsequent cytotoxicity assay of NGS on a green alga Chlamydomonas sp. signified non‐toxic nature. This study suggests NGS to be a promising economic adsorbent for water remediation in resource‐poor environments to fulfill “UN‐Sustainable Development Goal‐ 6”.

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“…Based on this, the total amount of ATZ used nationwide could reach 10 8 kg by the end of 2018. ATZ can be excreted in wastewater on a variety of environmental substrates, for example, ground and surface water, various sediments, potable water, and soil [8]. The amount of ATZ in ground and surface water and soil can continue increasing because of its heavy use and chemical stability [9].…”

Section: Introductionmentioning

confidence: 99%

Heat/PMS Degradation of Atrazine: Theory and Kinetic Studies

et al. 2022

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The degradation effect of heat/peroxymonosulfate (PMS) on atrazine (ATZ) is studied. The results show that the heat/PMS degradation for ATZ is 96.28% at the moment that the phosphate buffer (PB) pH, temperature, PMS dosage, ATZ concentration, and reaction time are 7, 50 °C, 400 μmol/L, 2.5 μmol/L, and 60 min. A more alkaline PB is more likely to promote the breakdown of ATZ through heat/PMS, while the PB alone has a more acidic effect on the PMS than the partially alkaline solution. HO• and SO4−• coexisted within the heat/PMS scheme, and ATZ quantity degraded by HO• and SO4−• in PB with pH = 7, pH = 1.7~1. HCO3− makes it difficult for heat/PMS to degrade ATZ according to inorganic anion studies, while Cl− and NO3− accelerate the degradation and the acceleration effect of NO3− is more obvious. The kinetics of ATZ degradation via heat/PMS is quasi-first-order. Ethanol (ETA) with the identical concentration inhibited ATZ degradation slightly more than HCO3−, and both of them reduced the degradation rates of heat/PMS to 7.06% and 11.56%. The addition of Cl− and NO3− increased the maximum rate of ATZ degradation by heat/PMS by 62.94% and 189.31%.

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Does diclofenac act like a photosynthetic herbicide on green algae? Chlamydomonas reinhardtii synchronous culture-based study with atrazine as reference

Cited by 22 publications

References 72 publications

Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii

Diclofenac Alters the Cell Cycle Progression of the Green Alga Chlamydomonas reinhardtii

Nitrogen‐Doped Graphene Nanosheets for Sustainable Removal of Pharmaceutical Contaminants from Water: Kinetics and ANFIS Modeling

Heat/PMS Degradation of Atrazine: Theory and Kinetic Studies

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