Does Curettage without Adjuvant Therapy Provide Low Recurrence Rates in Giant-Cell Tumors of Bone?

The prognostic factors of recurrent GCT: a cooperative study by the Eastern Asian Musculoskeletal Oncology Group

“…The incidence of lung metastasis seems to be high compared to the previously reported incidence in a general GCT population (approximately 3%) 17,18 . However, the cohort of patients in this study includes only those patients with recurrent GCT, and this may form a selection bias towards patients with a higher risk of metastasis.…”

“…Proccer et al 17 , O'Donnell et al 8 , and Rock 24 reported a correlation of recurrence with Grade III tumors. In this study, we focused only on recurrent GCT patients.…”

“…Prosser et al 17 performed repeat curettage after the local recurrence of GCT in 43 cases with a 100% success rate in patients who had previously undergone curettage in the author's hospital, and a 79.3% success rate in patients referred from elsewhere. They concluded that in most cases recurrence or the degree of the soft tissue involvement precludes it, recurrence could be treated with curettage with a reasonable chance of success.…”

“…The incidence of local recurrence, lung metastasis after treatment of primary GCT, and malignant transformation have been described 1,2,6,7,[13][14][15][16] . However, the clinical behavior of recurrent GCT, treatment strategy, and the factors affecting the clinical outcome has not been fully ellucidated [17][18][19][20][21][22] . In this multi-center study by the Eastern Asian Musculoskeletal Oncology Group (EAMOG), we retrospectively investigate the prognosis for 110 patients with recurrent GCT of bone in the extremities, and we examine the potential factors affecting the clinical outcome of these patients.…”

Which Treatment is the Best for Giant Cell Tumors of the Distal Radius? A Meta-analysis

“…GCTs typically affect young adults between the ages of 20 and 40 years [16,37,50], and occur somewhat more commonly in women [2,4,7,16,28]. GCTs have occurred in the distal radius in approximately 10% of cases (range, 8%-13%) [7,16,19,28,38,40], whereas more common sites have included the distal femur and proximal tibia. Local control and reconstruction of GCTs in the distal end of the radius have been challenging owing to the limited amount of surrounding soft tissue, the proximity of this region to adjacent neurovascular structures, and the juxtaarticular location.…”