Does COVID-19 Vaccination Warrant the Classical Principle “ofelein i mi vlaptin”?

Abstract

The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic warrants an imperative necessity for effective and safe vaccination, to restrain Coronavirus disease 2019 (COVID-19) including transmissibility, morbidity, and mortality. In this regard, intensive medical and biological research leading to the development of an arsenal of vaccines, albeit incomplete preconditioned evaluation, due to emergency. The subsequent scientific gap raises some concerns in the medical community and the general public. More specifically, the accelerated vaccine development downgraded the value of necessary pre-clinical studies to elicit medium- and long-term beneficial or harmful consequences. Previous experience and pathophysiological background of coronaviruses’ infections and vaccine technologies, combined with the global vaccines’ application, underlined the obligation of a cautious and qualitative approach, to illuminate potential vaccination-related adverse events. Moreover, the high SARS-CoV-2 mutation potential and the already aggregated genetical alterations provoke a rational vagueness and uncertainty concerning vaccines’ efficacy against dominant strains and the respective clinical immunity. This review critically summarizes existing evidence and queries regarding SARS-CoV-2 vaccines, to motivate scientists’ and clinicians’ interest for an optimal, individualized, and holistic management of this unprecedented pandemic.

PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation

“…Generally speaking, potential risks include local and systemic inflammatory responses and toxic effects of synthetic nucleosides and components for vaccine delivery. 16 These risks are generally low but can be more relevant in risk categories such as immune-depressed or immune-compromised patients. Mostly unexplored in the literature is the specific opportunity to develop COVID-19-like symptoms following vaccinations which create the SARS-CoV-2 spike protein, which starts to be covered consistently in the literature.…”

Quercetin Supplementation and COVID-19

“…mRNA vaccines 24-26 have potential risks of local and systemic inflammatory responses and toxic effects of synthetic nucleosides and components for vaccine delivery. 27…”

Decision Analysis of the COVID-19 Vaccines

“…The human COVID-19 vaccines are further classified into two major groups namely; Virus-based and Protein-based vaccines (16). The concept used in the human-based approach includes Purified proteins from viruses, virus-infected cells, recombinant proteins, and virus-like particles (VLP) (16). VLPs are structural protein fragments that can form a virus fragment but do not carry a viral genome.…”

“…In these vaccines, adjuvants are used to create a strong immune response. Adjuvants are added to stimulate the immune system stronger (16). Virus based vaccines can either be inactive and live-atenue vaccines.…”

“…Virus based vaccines can either be inactive and live-atenue vaccines. The virus in Live-Atenue vaccines is introduced into a cell culture until it becomes disease-free (16). It is injected into the human host to elicit immunity thereby causing a very mild reaction.…”