Does COVID-19 infection influence patients’ performance during IVF-ET cycle?: an observational study

Orvieto, Raoul; Segev-Zahav, Aliza; Aizer, Adva

doi:10.1080/09513590.2021.1918080

Cited by 67 publications

(83 citation statements)

References 17 publications

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“…The study included 9 couples, of which 7 women and 2 men were exposed. They reported a lack of any signi cant difference in IVF cycle outcomes between the exposed and non-exposed groups, other than a signi cant decrease in top quality embryo rate among exposed couples [18]. In our study neither patients conceiving immediately following recovery from COVID -19, nor those that contracted the infection during the rst trimester showed an increased rate of early pregnancy loss.…”

Section: Discussioncontrasting

confidence: 71%

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IVF and Early Pregnancy Outcome in Recent COVID 19 Recoverees.

Yossef

Bentov

Gil

et al. 2021

Preprint

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Background: COVID-19 global pandemic has affected more than 250 million people so far. Data regarding potential effects on reproduction are still limited. Our aim was to examine the effect of COVID-19 on post exposure IVF cycle parameters and obstetric outcomes of IVF-achieved pregnancies.The study contained two arms: a retrospective arm comparing IVF outcome parameters among patients exposed to COVID-19 having an IVF cycle within 3 months of exposure. Post COVID-19 cycle parameters were compared to previous cycles of the same individual, performed within one year of exposure. If not available, parameters were compared to non-exposed matched patients. Sperm parameters were compared before and after exposure. The second arm was prospective comparing pregnancy outcomes among IVF patients who contracted COVID-19 during pregnancy, vs. those who did not. Results: The first arm included 120 cycle of which 60 were in exposed female patients and another 60 in either the same patients prior to exposure or matched non exposed patients. Generally, total FSH dose, cycle length, and ovarian response did not significantly differ across exposure groups: including peak serum estradiol, number of oocytes and endometrial thickness, fertilization rate and number of top-quality embryos, were similar between exposed and non-exposed cycles. In 11 of the cycles in which the female partner was exposed the male partner had been recently exposed as well. In these couples, sperm quality showed a significantly lower post-exposure concentration: 6.27million/ml vs. 16.5 (p= 0.008). Interviews conducted in 189 patients with IVF-achieved pregnancies: pregnancy loss was as well as other pregnancy related complications and hospital admissions did not differ between groups. Conclusion: IVF treatment parameters and IVF-achieved pregnancies appear to be unaffected by SARS-CoV-2 exposure and do not involve an excess risk. Sperm concentration seems to be compromised.

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Section: Discussioncontrasting

confidence: 71%

“…Another small study from Israel examined the effect of COVID-19 on IVF treatment outcomes [18]. The study included 9 couples, of which 7 women and 2 men were exposed.…”

Section: Discussionmentioning

confidence: 99%

IVF and Early Pregnancy Outcome in Recent COVID 19 Recoverees.

Yossef

Bentov

Gil

et al. 2021

Preprint

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“…While the results of the number of oocytes obtained and fertilization rate were similar, the number of top-quality embryos (TQE) was significantly lower. TQE was considered an embryo with more than seven blastomeres on day 3, ≤10% fragmentation, and blastomeres of equal size [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Orvieto et al found a low TQE rate in 9 couples undergoing IVF procedures in their clinic before and after COVID-19 infection, but they evaluated day-3 embryos. As the procedures were conducted between 8 and 92 days post-infection, taking into consideration the results, the authors recommended postponing the IVF procedures for three months [ 58 ]. In concordance with these findings, Chamani et al found a significantly lower mean number of euploid embryos per patient [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

Carp-Velişcu

Mehedințu

Frîncu

et al. 2022

IJERPH

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As the coronavirus pandemic is far from ending, more questions regarding the female reproductive system, particularly fertility issues, arise. The purpose of this paper is to bring light upon the possible link between COVID-19 and women’s reproductive health. This review emphasizes the effect of SARS-CoV-2 on the hormones, endometrium and menstrual cycle, ovarian reserve, follicular fluid, oocytes, and embryos. The results showed that endometrial samples did not express SARS-CoV-2 RNA. Regarding the menstrual cycle, there is a large range of alterations, but they were all reversible within the following months. The ovarian reserve was not significantly affected in patients recovering from both mild and severe infection in most cases, except one, where the levels of AMH were significantly lower and basal follicle-stimulating hormone (FSH) levels were increased. All COVID-19 recovered patients had positive levels of SARS-CoV-2 IgG in the follicular fluid. The amount of retrieved and mature oocytes and the fertilization rate were unharmed in three studies, except for one study, where the quantity of retrieved and mature oocytes was reduced in patients with higher levels of SARS-CoV-2 antibodies. The numbers of blastocysts, top-quality embryos, and euploid embryos were affected in most of the studies reviewed.

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“…23 However, most clinical studies subsequently showed that the ovarian function and IVF outcomes did not obviously change in patients with a history of infection. 14,[24][25][26] Regarding the COVID-19 vaccine, immunity-related effects have been suggested to be the biological mechanisms linked with potential infertility. On the one hand, immune cells are involved in the intra-ovarian processes and release of cytokines required for normal follicular development.…”

mentioning

confidence: 99%

No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

Huang¹,

Xia²,

Lin³

et al. 2022

JIR

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To investigate the impact of inactivated SARS-CoV-2 vaccination on in vitro fertilization (IVF) outcomes. Patients and Methods: This retrospective cohort study included 2185 patients undergoing fresh IVF cycles from June 1st to September 13th 2021 in a single university-affiliated hospital. Vaccine administration information was collected and ascertained via immunization records. Patients with two dosages of inactivated SARS-CoV-2 vaccines (Sinopharm or Sinovac) were categorized into the vaccinated group (n = 150), while those unvaccinated were classified as control (n = 2035). Propensity score matching was performed to balance the baseline characteristics (14 covariates) between the two groups at a ratio of 1:4. The main outcome measures were the number of oocytes retrieved, good-quality embryo rate and clinical pregnancy rate. Results: There were 146 women in the vaccinated group and 584 in the control group after matching. The number of oocytes retrieved (9.9 ± 7.1 vs 9.9 ± 6.7; P = 0.893), good-quality embryo rate (33.5 ± 29.8% vs 29.9 ± 28.6%; P = 0.184) and clinical pregnancy rate (59.1% vs 63.6%; P = 0.507) were all similar between the two groups. In addition, no significant differences were observed regarding other cycle characteristics, laboratory parameters and pregnancy outcomes. The results were also comparable when vaccinated patients were subdivided into three categories based on the time interval from complete vaccination to cycle initiation: ≤1 month, >1-2 months, and >2 months. Conclusion:Our study provided the first-time evidence that inactivated SARS-CoV-2 vaccination in females did not result in any measurable detrimental effects on IVF treatment. Owing to the present limitations, further prospective studies with larger cohort size and longer follow-up are warranted to validate our conclusion.

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Does COVID-19 infection influence patients’ performance during IVF-ET cycle?: an observational study

Cited by 67 publications

References 17 publications

IVF and Early Pregnancy Outcome in Recent COVID 19 Recoverees.

IVF and Early Pregnancy Outcome in Recent COVID 19 Recoverees.

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature

No Effect of Inactivated SARS-CoV-2 Vaccination on in vitro Fertilization Outcomes: A Propensity Score-Matched Study

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