Does concomitant glucose and glutamine supplementation change the response of glutamine synthetase to fasting in healthy adult rats?

Mignon, M; Lêvêque, Loïc; Bonnel, Emilie; Meynial-Denis, Dominique

doi:10.1016/j.clnu.2007.03.001

Cited by 2 publications

(1 citation statement)

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“…This feedback inhibition may be relieved upon the removal of glutamine by glutaminase; however, this in turn produces ammonia and contributes to hyperammonemia. Removing glutamine by phenylacetate relieves GS inhibition, allowing for further glutamine production and ammonia removal and contributes to lowering blood ammonia 32–34. Our data suggest that OP treatment lowers ammonia systemically in ALF animals and subsequently attenuates the concentration of ammonia in the brain.…”

Section: Discussionmentioning

confidence: 64%

L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure

et al. 2009

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Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing glutamine production (ammonia removal) through muscle glutamine synthetase and (2) I n patients with acute liver failure (ALF) increased intracranial pressure (ICP) leads to brain herniation, which accounts for 30% of deaths. 1 Liver failure results in hyperammonemia, which leads to toxic levels of ammonia in the brain. In patients with ALF, an arterial ammonia level of Ͼ150 mol/L has been shown to correlate with severity of intracranial hypertension 2 and deaths from brain herniation. 3 More recently, ammonia levels were shown to be predictive of increased ICP 4 and changes in blood ammonia concentration determined death due to cerebral edema in patients with ALF. 5Abbreviations: ALF, acute liver failure; GS, glutamine synthetase; HE, hepatic encephalopathy; ICP, intracranial pressure; OP, L-ornithine phenylacetate. From the

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Section: Discussionmentioning

confidence: 64%