Does Complete Resection of Melanoma Metastatic to Solid Intra-Abdominal Organs Improve Survival?

Abstract

In highly selected patients with melanoma metastatic to intra-abdominal solid organs, aggressive attempts at complete surgical resection may improve OS. It is important that the number of metastatic sites does not seem to affect the OS after complete resection.

Surgery and adjuvant therapies in the treatment of stage IV melanoma: our experience in 84 patients

“…In many cases, it is palliative, improving symptoms and quality of life; in selected cases, it can be able to increase overall survival (OS) [3].…”

Splenectomy for non-haematological metastatic malignant disease

“…Patients who have been felt to be suitable for resection of (stage IV) metastatic melanoma have an improved survival over those treated palliatively, with median survival times of 11-27 months [9,25] compared with 4-14 months in patients not undergoing splenectomy [9,25]. Very occasionally, longterm disease-free survival after metastatectomy for malignant melanoma has been described [9], but the median time to disease recurrence is 2 months [9] and in patients where it is not possible to achieve an R0 resection, outcome is similar to non-operative management [25].…”

“…Patients with tumours with the least aggressive natural course, those most sensitive to chemotherapy and those with an improvement in outcome associated with cytoreductive surgery [21,22] are those who are most likely to benefit from resection of their splenic disease whereas no benefit is seen in incomplete resection of disease in other tumours [25].…”

Metastatic lesions to the liver: Surgical indications and techniques

“…Previou patients with m Diagnosis is g FDG PET/CT survival in the prolong surviv durable [96] . Ne Table 7.…”

“…Ne Table 7. Liver Author Rose [93] Wood [100] Hsueh [101] Pawlik [98] Crook [102] Adam [49] Herman [103] Chua [104] A and a slowing o Table 7). A larg ma of choroida rce [49] .…”