This chapter uses the longitudinal data for Ethiopia, Malawi, Tanzania and Uganda to investigate some dynamic links between disability and wellbeing. The functional difficulty trajectories of individuals are significantly associated with different levels of wellbeing. Persons with persistent functional difficulties are worse off than persons with functional difficulties in one or no period. Women with persistent difficulties and older persons with persistent difficulties are the most deprived groups. New functional difficulties lower the odds to continue working and no longer reporting any difficulty increases the odds of returning to work. Functional difficulties are also associated with mortality in the short-term. More research is needed on the links between disability, on the one hand, and poverty dynamics and mortality, on the other.