Does Combing <scp>O‐RADS US</scp> and <scp>CA</scp>‐125 Improve Diagnostic Accuracy in Assessing Adnexal Malignancy Risk in Women With Different Menopausal Status?

Wu, Manli; Wang, Qingjuan; Zhang, Man; Cao, Junyan; Chen, Ying; Zheng, Jinhai; Luo, Liping; Su, Manting; Lin, Xin; Kuang, Xiaohong; Zhang, Xinling

doi:10.1002/jum.16065

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Several researchers have demonstrated that O-RADS US has high reliability, with an AUC of 0.91-0.98, in predicting malignancy risk in adnexal areas [28], and those data are within the scope of the present study's data. This indicates that O-RADS US can be an effective means for the diagnosis and treatment of ovarian-adnexal masses.…”

Section: Discussionsupporting

confidence: 51%

Application of O-RADS US combined with MV-Flow to diagnose ovarian-adnexal tumors

Ruan,

Liu,

Xiang

et al. 2024

Ultrasonography

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Purpose: This study aimed to explore the application of Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) combined with MV-Flow (Samsung Medison Co., Ltd.) to diagnose ovarian-adnexal masses.Methods: A total of 112 ovarian-adnexal masses (81 benign and 31 malignant) from 105 consecutive patients were analyzed. The O-RADS US and vascular index from MV-Flow (VI<sup>MV</sup>) were measured and compared with the reference standard. O-RADS US and MV-Flow were tested for consistency.Results: Receiver operating characteristic curves were drawn for O-RADS US, MV-Flow, and their combination. The combined methods had the largest area under the curve (0.955), followed by O-RADS US (0.929) and MV-Flow (0.923). A mass was considered malignant when the O-RADS US classification was 5 and VI<sup>MV</sup> was ≥7.15. With this definition, MV-Flow had the highest sensitivity (87.10%), with consistent findings for the combined diagnostic methods and O-RADS US (83.87%). The specificity of the combined diagnostic methods (93.83%) was higher than that of MV-Flow (91.36%). O-RADS US had the lowest specificity (90.12%). The combined diagnostic methods had the highest coincidence rate (91.07%), and MV-Flow (90.18%) had a significantly higher coincidence rate than O-RADS US (88.39%). Both O-RADS US and MV-Flow showed good consistency among different physicians (former kappa, 0.974; latter intraclass correlation coefficient [ICC], 0.986). MV-Flow had a high consistency for the same physician (ICC, 1).Conclusion: O-RADS US and MV-Flow exhibited good diagnostic efficacy, and their combined diagnostic efficacy was higher than that of each individually. O-RADS US and MV-Flow can improve the diagnosis of benign and malignant ovarian-adnexal masses.

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Section: Discussionsupporting

confidence: 51%

Application of O-RADS US combined with MV-Flow to diagnose ovarian-adnexal tumors

Ruan,

Liu,

Xiang

et al. 2024

Ultrasonography

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“…A recent study [35] indicated that a combination of O-RADS, SR and CA125 had a significantly higher AUC in discriminating ovarian tumors than individual approaches, but it did not provide the specific method. Wu et al [36] developed a model of combining O-RADS and CA125, and the results suggested that the model significantly increased the diagnostic performance of malignancy risk estimation in adnexal masses. In addition, the model also showed good results in distinguishing certain subtypes of ovarian tumors.…”

Section: Discussionmentioning

confidence: 99%

Nomogram based on the O-RADS for predicting the malignancy risk of adnexal masses with complex ultrasound morphology

Gong

et al. 2023

J Ovarian Res

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Objective The accurate preoperative differentiation of benign and malignant adnexal masses, especially those with complex ultrasound morphology, remains a great challenge for junior sonographers. The purpose of this study was to develop and validate a nomogram based on the Ovarian-Adnexal Reporting and Data System (O-RADS) for predicting the malignancy risk of adnexal masses with complex ultrasound morphology. Methods A total of 243 patients with data on adnexal masses with complex ultrasound morphology from January 2019 to December 2020 were selected to establish the training cohort, while 106 patients with data from January 2021 to December 2021 served as the validation cohort. Univariate and multivariate analyses were used to determine independent risk factors for malignant tumors in the training cohort. Subsequently, a predictive nomogram model was developed and validated in the validation cohort. The calibration, discrimination, and clinical net benefit of the nomogram model were assessed separately by calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). Finally, we compared this model to the O-RADS. Results The O-RADS category, an elevated CA125 level, acoustic shadowing and a papillary projection with color Doppler flow were the independent predictors and were incorporated into the nomogram model. The area under the ROC curve (AUC) of the nomogram model was 0.958 (95% CI, 0.932–0.984) in the training cohort. The specificity and sensitivity were 0.939 and 0.893, respectively. This nomogram also showed good discrimination in the validation cohort (AUC = 0.940, 95% CI, 0.899–0.981), with a sensitivity of 0.915 and specificity of 0.797. In addition, the nomogram model showed good calibration efficiency in both the training and validation cohorts. DCA indicated that the nomogram was clinically useful. Furthermore, the nomogram model had higher AUC and net benefit than the O-RADS. Conclusion The nomogram based on the O-RADS showed a good predictive ability for the malignancy risk of adnexal masses with complex ultrasound morphology and could provide help for junior sonographers.

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A modified CEUS risk stratification model for adnexal masses with solid components: prospective multicenter study and risk adjustment

Wu,

Zhang,

et al. 2024

Eur Radiol

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Does Combing O‐RADS US and CA‐125 Improve Diagnostic Accuracy in Assessing Adnexal Malignancy Risk in Women With Different Menopausal Status?

Cited by 6 publications

References 25 publications

Application of O-RADS US combined with MV-Flow to diagnose ovarian-adnexal tumors

Application of O-RADS US combined with MV-Flow to diagnose ovarian-adnexal tumors

Nomogram based on the O-RADS for predicting the malignancy risk of adnexal masses with complex ultrasound morphology

A modified CEUS risk stratification model for adnexal masses with solid components: prospective multicenter study and risk adjustment

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