Does colorectal cancer clinical advancement affect adhesion molecules (sP- selectin, sE- selectin and ICAM-1) concentration?

Dymicka-Piekarska, Violetta; Kemona, H

doi:10.1016/j.thromres.2008.11.021

Cited by 47 publications

(49 citation statements)

References 21 publications

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“…The targeting of inflammatory mediators (chemokines and cytokines, such as TNF-α and IL-1β), key transcription factors involved in inflammation (such as NF-κB and STAT3) or inflammatory cells decreases the incidence and spread of cancer (40). In various cancers, ICAM- 1 expression is at an elevated level and is associated with the malignant potential of cancer (5)(6)(7)(8)(9). To some extent, ICAM-1 overexpression is associated with the inflammatory environment in tumors.…”

Section: Discussionmentioning

confidence: 99%

“…ICAM-1 is widely expressed at a low basal level and is upregulated by inflammatory cytokines (TNF-α, IL-1, IFN-γ) in endothelial cells. In various cancers, such as non-small cell lung cancer (5), breast cancer (6), gastric cancer (7), colorectal cancer (8), and bladder cancer (9), ICAM-1 expression is at an elevated level and is associated with the malignant potential of cancer. Increasing evidence suggest that ICAM-1 plays an important role in the adhesion of tumor cells to endothelial cell monolayers and subsequent transendothelial migration (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Effect of mild hypothermia on breast cancer cells adhesion and migration

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of mild hypothermia on breast cancer cells adhesion and migration

et al. 2012

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“…Previous studies have demonstrated that sE-selectin is highly expressed in colorectal cancer and is closely associated with the progression, recurrence and metastasis of cancer (31,32). It was observed that the serum levels of sE-selectin were significantly increased in CSCC patients and were correlated with FIGO stage and tumor size.…”

Section: ------------------------------------------------------------mentioning

confidence: 93%

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Zhang

Yang

et al. 2014

Molecular Medicine Reports

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Abstract. The aim of the present study was to evaluate the clinical significance and prognostic value of growth-regulated oncogene-1 (GRO-1), hepatocyte growth factor (HGF), platelet-derived growth factor-AA (PDGF-AA), soluble E-selectin (sE-selectin) and high-risk human papillomavirus (HPV; types 16, 18/45, 31 and 33/52/58/67) infection in cervical squamous cell carcinoma (CSCC). A total of 426 cases were enrolled in the present study, of which 292 cases were patients with CSCC, 43 were patients with cervical intraepithelial neoplasia (CIN) and 91 were healthy controls. Luminex xMAP technology was used to detect the serum levels of GRO-1, HGF, PDGF-AA and sE-selectin in all cases and two-channel fluorescence quantitative polymerase chain reaction was used to determine HPV DNA in cervical scrapings from CSCC and CIN patients. The results demonstrated that the serum levels of GRO-1, HGF and sE-selectin were significantly higher in patients with CSCC compared with patients with CIN and the healthy controls (P<0.0001). Compared with the CIN patients, the HPV positive rate in the CSCC patients significantly increased (P= 0.013). The four factors were correlated with certain clinicopathological variables of CSCC patients to a certain degree (P<0.05) and the levels of HGF were closely associated with HPV infection (P= 0.039). The receiver operating characteristic curves demonstrated that HGF obtained the highest diagnostic value compared with the other three factors. Multivariate Cox regression analysis demonstrated that the serum levels of HGF (P<0.0001), FIGO stage (P<0.0001) and pelvic lymph node metastasis (P=0.001) were independent prognostic factors in patients with CSCC, while high-risk HPV infection did not show any significance in this analysis. These results demonstrated that HGF may be a useful prognostic biomarker rather than high-risk HPV types in patients with CSCC.

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“…49 To demonstrate the relationship between P-selectin and anticancer activity, the effect of PZL318 on the P-selectin expression of AA-activated rat platelets was examined. Figure 11A shows that in vitro, 1 μM of PZL318 effectively downregulates AA-activated rat platelets expressing P-selectin.…”

Section: Pzl318 Downregulating P-selectin and Scavenging Free Radicalsmentioning

confidence: 99%

Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis

Wang

et al. 2015

IJN

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Low selectivity of chemotherapy correlates with poor outcomes of cancer patients. To improve this issue, a novel agent, N-(1-[3-methoxycarbonyl-4-hydroxyphenyl]-β-carboline-3-carbonyl)-Trp-Lys-OBzl (PZL318), was reported here. The transmission electron microscopy, scanning electron microscopy, and atomic force microscopy images demonstrated that PZL318 can form nanoparticles. Fluorescent and confocal images visualized that PZL318 formed fluorescent nanoparticles capable of targeting cancer cells and tracing their interactions with cancer cells. In vitro, 40 μM of PZL318 inhibited the proliferation of tumorigenic cells, but not nontumorigenic cells. In vivo, 10 nmol/kg of PZL318 slowed the tumor growth of S180 mice and alleviated the thrombosis of ferric chloride-treated ICR mice, while 100 μmol/kg of PZL318 did not injure healthy mice and they exhibited no liver toxicity. By analyzing Fourier transform–mass spectrometry and rotating-frame Overhauser spectroscopy (ROESY) two-dimensional nuclear magnetic resonance spectra, the chemical mechanism of PZL318-forming trimers and nanoparticles was explored. By using mesoscale simulation, a nanoparticle of 3.01 nm in diameter was predicted containing 13 trimers. Scavenging free radicals, downregulating sP-selectin expression and intercalating toward DNA were correlated with the antitumor mechanism of PZL318.

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Does colorectal cancer clinical advancement affect adhesion molecules (sP- selectin, sE- selectin and ICAM-1) concentration?

Cited by 47 publications

References 21 publications

Effect of mild hypothermia on breast cancer cells adhesion and migration

Effect of mild hypothermia on breast cancer cells adhesion and migration

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis

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