Does circulating erythropoietin reflect progression of IgA nephropathy? Comparison with urinary N-acetyl- -D-glucosaminidase

Machiguchi, Toshihiko; Yoshida, Haruyoshi; Yonemoto, Satomi; Minakata, Tamotsu; Nomura, Keiko; Muso, Eri; Tamura, Tadao; Sasayama, Shígetake

doi:10.1093/ndt/14.3.635

Cited by 18 publications

(19 citation statements)

References 1 publication

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“…This finding is in agreement with studies showing that NGAL predominantly reflects tubular damage in acute conditions [25,26]. A comparable association was already explored about ten years ago for IgA nephropathy; urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of tubular injury, correlated with EPO levels [27]. Also, several animal studies show a direct cytoprotective effect of ESA on intrinsic renal cells [28,29].…”

Section: Discussionsupporting

confidence: 89%

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

Emans

Braam

Diepenbroek

et al. 2012

Kidney Blood Press Res

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Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p<0.001) and baseline EPO levels (r=-0.395, p=0.003). There was no correlation with baseline TSAT, Ret-He, and hepcidin-25 levels. After two weeks, NGAL levels decreased in the ESA-group (p=0.02), while there was no change in the no-ESA group (p=0.62). The magnitude in NGAL decrease in the ESA-group correlated with baseline EPO levels (r=0.431, p=0.01). Conclusions: In contrast to in HD patients, in combined CKD/ CHF, serum NGAL levels did not correlate with iron metabolism, hence NGAL might reflect tubular damage in these patients. NGAL levels inversely correlated with baseline EPO levels and decreased in response to short-term ESA treatment, which might reflect an effect of ESA on tubular damage. These findings need to be confirmed and alternative explanations should be evaluated.

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Section: Discussionsupporting

confidence: 89%

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

Emans

Braam

Diepenbroek

et al. 2012

Kidney Blood Press Res

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“…Moreover, the scores for both glomerular obsolescence and interstitial fibrosis correlated positively with urinary NAG levels. These results indicate that urinary NAG measurement may be a highly beneficial clinical marker of the severity of IgA nephropathy (40,41). The pathogenic mechanisms through which proteinuria induces the appearance of interstitial infiltrates and progressive tubulointerstitial fibrosis have been partially clarified.…”

Section: Discussionmentioning

confidence: 93%

Low-Dose Losartan Therapy Reduces Proteinuria in Normotensive Patients with Immunoglobulin A Nephropathy

et al. 2008

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“…Fibrosis and/or inflammatory cell infiltration in the tubulointerstitial region were marked in Group IV among the four groups in this study. In 1999, Machiguchi et al (20) reported that the mean level of (20). Thus, it is postulated that EPO production in Group IV may be decreased compared to that in other groups.…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult to clarify the increase of serum EPO levels in Group IV. Machiguchi et al (20) showed that the mean s-Cr level was 0.9570.43 (range=0.5-2.2 mg/dl). In this study, there were no significant changes in the levels of s-Cr and CCr among the four groups of IgA nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Relationship between renal anemia and prognostic stages of IgA nephropathy

Aruga

Horiuchi

Shou

et al. 2005

Clinical Laboratory Analysis

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In 2002, the Joint Committee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health, Labor and Welfare of Japan newly revised the clinical guidelines for IgA nephropathy (Sakai et al.: Jpn J Nephrol 37:417-421, 1995; Tomino and Sakai: Clin Exp Nephrol, 7, 93-97, 2003). The prognostic stages were classified into four groups: the good prognosis group (Group I), relatively good prognosis group (Group II), relatively poor prognosis group (Group III), and poor prognosis group (Group IV). The relationship between the levels of Hb, Ht, and RBC in peripheral blood and the renal prognostic stages was determined in 62 patients with IgA nephropathy in the present study. The mean levels of Hb, Ht, and RBC were significantly lower in Group IV than in Group I (P<0.05). However, there were no significant changes in the levels of serum creatinine (s-Cr) or creatinine clearance (CCr) among these four groups. It appears that the levels of Hb, Ht, and RBC in peripheral blood may be important clinical parameters for the evaluation of prognostic stages in patients with IgA nephropathy.

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Does circulating erythropoietin reflect progression of IgA nephropathy? Comparison with urinary N-acetyl- -D-glucosaminidase

Cited by 18 publications

References 1 publication

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

Low-Dose Losartan Therapy Reduces Proteinuria in Normotensive Patients with Immunoglobulin A Nephropathy

Relationship between renal anemia and prognostic stages of IgA nephropathy

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