Does cigarette smoking really have a clinical effect on folliculogenesis and oocyte maturation?

Ozbakir, Burcu; Tulay, Pınar

doi:10.1017/s0967199420000155

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…Remarkably, the sperm counts in the rats handled by the non-nicotine liquid was 32.3 ± 3.0 million/mL or 38.4 ± 0.9 million/mL, accordingly, compared to the other subgroup handled with nicotine. Assessing the vitality of sperm for treated rats yielded similar findings, with 27.0% ± 4.6% to 42.8% ± 5.1% of viable sperm [39]. A morphological analysis revealed a statistically significant rise in the proportion of aberrant sperm, particularly in the rats subjected to the nicotinefree liquid compared to the nicotine-containing liquid compared the untreated group, at 43.0% ± 1.0% vs. 30.2% ± 1.8% vs. 24.0% ± 0.9%.…”

Section: Issn: 2583-4053mentioning

confidence: 58%

“…The World Health Organisation (WHO) reports that 30% of males aged 15 or older smoke [6][7]. About 46% of smokers are men who are of age to reproduce (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). The real number of smokers climbed from 721 million in 1980 to 967 million for 2012, despite the fact that the proportion of adult smokers, based By the World Health Organisation, infertile affects 8% for spouses globally including 10% -15% of spouses throughout developed countries, with male factor contributing to 30% -35% of instances.…”

Section: Introductionmentioning

confidence: 99%

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Article Review: Effect of Electronic Cigarette on Fertility in Male

Abud

2024

J. Res. Appl. Sci. Biotechnol.

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Numerous researches have shown that blood plasma, sperm parameters, or a host of other fertility-related characteristics are adversely affected by the components of cigarette smoking. However, it's unclear how smoking really affects fertility in men. Depending on the well-established scientific observation that smoking enhances the amount of radical oxide organisms, which in turn causes oxidative stress (OS), smoking has an influence on the sperm variables. Men are affected by OS as it damages seminal characteristics including survival that appearance as well as inhibits sperm functioning. Still, not every research has reached identical findings. This research evaluates the influence of tobacco use via non-smoking methods on male infertility on clarifies the contentious relationship among smoking on fertility in men. Additionally, it explores the therapeutic consequences of the evidence—which includes recently discovered genomic or regulatory data—that tie smoking to male infertility.

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Section: Issn: 2583-4053mentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Article Review: Effect of Electronic Cigarette on Fertility in Male

Abud

2024

J. Res. Appl. Sci. Biotechnol.

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“…Thus, differences in study populations can't be excluded. Previous reports suggested that some diseases, e.g., endometriosis [98-101], and even some social habits, e.g., smoking [102], may have detrimental effects on oocyte morphology and quality. In our studies, there were no signi cant differences between the two groups in any patient's characteristics.…”

Section: Discussionmentioning

confidence: 99%

Effect of Flexible GnRH antagonist and long GnRH agonist protocols on follicular fluid levels of PlGF, AMH, oocyte’s morphology, and other IVF/ICSI outcomes in normo-ovulatory women

Kadoura

Alhalabi

Nattouf

2022

Preprint

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Background Gonadotropin-releasing hormone (GnRH) analogues are commonly used to prevent premature luteinizing hormone (LH) surge during In-Vitro Fertilization/ Intra-Cytoplasmic Sperm Injection (IVF/ICSI) cycles in routine practice. However, it is still unclear whether they have different effects on the follicular microenvironment in normo-ovulatory women. Settings: This study was performed at Orient Hospital, Damascus, Syrian Arab Republic, from December 2019 to August 2021. Methods In this interventional, prospective, parallel, non-randomized, open-label controlled clinical trial, a total of 83 normo-ovulatory women were allocated to take either the long GnRH agonist protocol (n = 50) or the flexible GnRH antagonist protocol (n = 33). The trial was originally designed to be a randomized control trial. However, due to a lack in the drug supply during a certain point of the study duration, we used a non-random study design. Follicular fluid (FF) samples were collected on the retrieval day, and the FF levels of Placental growth factor (PlGF) and Anti-Müllerian hormone (AMH) were measured using ELISA Kits. Before being subjected to ICSI, the mature oocytes from both groups were morphologically assessed under an inverted microscope at 400x magnification. In addition, the embryological and clinical IVF/ICSI outcomes were detected. Results The two groups did not differ significantly in any of the baseline characteristics. The FF PlGF levels were significantly lower, while FFAMH levels were insignificantly higher in the GnRH antagonist group (FF PlGF; GnRH agonist = 140.46 ± 42.46 pg/ml vs. GnRH antagonist = 120.49 ± 35.07 pg/ml; P value = 0.029). (FF AMH; GnRH agonist = 7.40 ± 5.69 ng/ml vs. GnRH antagonist = 8.51 ± 7.93 ng/ml; P value = 0.440). The stimulation duration was significantly shorter in the GnRH antagonist group compared to the long-agonist one (GnRH agonist = 8.28 ± 1.09 days vs. GnRH antagonist = 7.26 ± 0.89 days; P value < 0.001). On the other hand, although the consumed dose of gonadotropin was lower in the antagonist group, the difference between the two groups was not statistically significant (GnRH agonist = 2523.00 ± 1034.11 IUs vs. GnRH antagonist = 2468.18 ± 879.53 IUs; P value = 0.952). However, there were not any significant differences between the two groups in embryological or clinical IVF/ICSI outcomes except for the endometrial thickness, which was thinner in the GnRH antagonist group, and the result almost reached significance level (GnRH agonist = 9.66 ± 1.39 mm vs. GnRH antagonist = 9.03 ± 1.51 mm; P value = 0.058). In addition, the morphological assessment of MII oocytes showed comparable oocytes morphology in both groups. Conclusions Flexible GnRH antagonist protocol and the long GnRH agonist protocol regulate the follicular microenvironment and angiogenesis differently in normo-ovulatory women. However, these differences have no influence on the oocyte’s morphology or the IVF/ICSI outcomes. In addition, although both protocols provide acceptable endometrial thickness, caution should be taken when designing the plans therapy for cases that are considered high risk of developing thin endometrial when stimulated with the flexible GnRH antagonist protocol. Study registration: This trial was prospectively registered at clinicaltrials.gov site under registration number (NCT04724343).

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“…They concluded that cigarette smoking did not affect the follicles count and the number of oocytes retrieved. However, a significant difference was detected in the morphological assessment of oocyte including cytoplasmic anomalies [126].…”

Section: Female Smoking and Assisted Reproductive Treatment (Art)mentioning

confidence: 95%

Smoking and Its Consequences on Male and Female Reproductive Health

Amor¹,

Michael²,

Romeo³

et al. 2022

Studies in Family Planning

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Smoking contributes to the death of around one in 10 adults worldwide. Specifically, cigarettes are known to contain around 4000 toxins and chemicals that are hazardous in nature. The negative effects of smoking on human health and interest in smoking-related diseases have a long history. Among these concerns are the harmful effects of smoking on reproductive health. Thirteen percent of female infertility is due to smoking. Female smoking can lead to gamete mutagenesis, early loss of reproductive function, and thus advance the time to menopause. It has been also associated with ectopic pregnancy and spontaneous abortion. Even when it comes to assisted reproductive technologies cycles, smokers require more cycles, almost double the number of cycles needed to conceive as non-smokers. Male smoking is shown to be correlated with poorer semen parameters and sperm DNA fragmentation. Not only active smokers but also passive smokers, when excessively exposed to smoking, can have reproductive problems comparable to those seen in smokers. In this book chapter, we will approach the effect of tobacco, especially tobacco smoking, on male and female reproductive health. This aims to take a preventive approach to infertility by discouraging smoking and helping to eliminate exposure to tobacco smoke in both women and men.

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Does cigarette smoking really have a clinical effect on folliculogenesis and oocyte maturation?

Cited by 8 publications

References 39 publications

Article Review: Effect of Electronic Cigarette on Fertility in Male

Article Review: Effect of Electronic Cigarette on Fertility in Male

Effect of Flexible GnRH antagonist and long GnRH agonist protocols on follicular fluid levels of PlGF, AMH, oocyte’s morphology, and other IVF/ICSI outcomes in normo-ovulatory women

Smoking and Its Consequences on Male and Female Reproductive Health

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