Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?

Оздемир, Рамазан; Gökçe, İsmail Kürşat; Taşlidere, Aslı; Tanbek, Kevser; Gül, Cemile Ceren; Sandal, Süleyman; Turgut, Hatice; Kaya, Hüseyin; Aslan, Mehmet

doi:10.1016/j.intimp.2021.108033

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Our study findings are that it increases the oxidative damage in the lung tissue and causes the deterioration of the antioxidant/oxidant balance. It shows that it may be beneficial to use it together with antioxidants mentioned in the literature to reduce the damage that may occur due to the use of MOL while preventing viral growth in the lung tissue [37].…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent Oxidative Damage of Molnupiravir (Antiviral Drug for Treatment of COVID-19) in Lung, Liver, Heart, and Kidney Tissues in Rats

TANBEK,

SANDAL

2023

Arch Pharmacol Ther

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Molnupiravir (MOL) is an orally absorbed prodrug of the ribonucleoside analogue N-hydroxycytidine, which has in vitro activity against several coronaviruses, including SARS-CoV-1 and 2. It remains to be seen whether long term MOL has serious side effects. The side effects of MOL, which was the first to be allowed for oral use during the pandemic process, are not yet fully known. In this study, it was aimed to investigate the the mechanisms of possible dose-dependent damage on liver, lung, heart, and kidney tissues. Fourty male Wistar albino rats were separated into four groups as Control, MOL10, MOL100, MOL1000. For five days, MOL (10-100-1000 mg/kg/day) was administered by oral gavaj. At the end of the five days rats were sacrificed and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TB) levels in serum were measured. Collected tissues (liver, lung, heart, and kidney) were evaluated to the malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant state (TAS), and total oxidant state (TOS), and oxidative stress indexes (OSI) were calculated. MOL administration showed significant improvement in liver, heart, and kidney in rats (p<0.05). SOD activities which were decreased in the MOL group, while MDA level increased in the MOL groups compared to the control group in all tissue (p<0.05). ALT was increased in the MOL group compared to the control group (p<0.05). Increase of TOS and OSI is statistically significant, but TAS was decreased in the MOL group compared to the control group (p<0.05). MOL used in virus treatment is dose-dependently effective on the oxidant/antioxidant system in tissues. For this reason, the use of antioxidants may be beneficial to reduce tissue damage that may occur in the use of MOL.

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Section: Discussionmentioning

confidence: 99%

Dose-dependent Oxidative Damage of Molnupiravir (Antiviral Drug for Treatment of COVID-19) in Lung, Liver, Heart, and Kidney Tissues in Rats

TANBEK,

SANDAL

2023

Arch Pharmacol Ther

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“…Inhibition of the ERK pathway by semaphorin 3A suppressed hyperoxia-induced apoptosis and inflammation [ 364 ]. Administration of chrysin (a flavonoid) attenuated lung damage via increased antioxidant activities (SOD and GSH), suppression of pro-inflammatory mediators (TNF-α and IL-1β), improving alveolarization, and reducing apoptosis (caspase 3) in an experimental model of hyperoxia-induced lung injury [ 365 ].…”

Section: Oxidative Stress and Inflammation In Hyperoxiamentioning

confidence: 99%

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Bezerra

Lanzetti

Nesi³

et al. 2023

Antioxidants

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Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung injury can affect several components of the respiratory system, including the airways, parenchyma, and pulmonary vasculature. Although acute and chronic lung injuries represent an enormous economic and clinical burden, currently available therapies primarily focus on alleviating disease symptoms rather than reversing and/or preventing lung pathology. Moreover, some supportive interventions, such as oxygen and mechanical ventilation, can lead to (further) deterioration of lung function and even the development of permanent injuries. Lastly, sepsis, which can originate extrapulmonary or in the respiratory system itself, contributes to many cases of lung-associated deaths. Considering these challenges, we aim to summarize molecular and cellular mechanisms, with a particular focus on airway inflammation and oxidative stress that lead to the characteristic pathophysiology of acute and chronic lung injuries. In addition, we will highlight the limitations of current therapeutic strategies and explore new antioxidant-based drug options that could potentially be effective in managing acute and chronic lung injuries.

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Recent progress in neonatal hyperoxic lung injury

Rao,

Zhou,

Chen

et al. 2024

Pediatric Pulmonology

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With the progress in neonatal intensive care, there has been an increase in the survival rates of premature infants. However, this has also led to an increased incidence of neonatal hyperoxia lung injury and bronchopulmonary dysplasia (BPD), whose pathogenesis is believed to be influenced by various prenatal and postnatal factors, although the exact mechanisms remain unclear. Recent studies suggest that multiple mechanisms might be involved in neonatal hyperoxic lung injury and BPD, with sex also possibly playing an important role, and numerous drugs have been proposed and shown promise for improving the treatment outcomes of hyperoxic lung injury. Therefore, this paper aims to analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis and treatment progress to provide new ideas for basic and clinical research in this field.

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Does Chrysin prevent severe lung damage in Hyperoxia-Induced lung injury Model?

Cited by 5 publications

References 43 publications

Dose-dependent Oxidative Damage of Molnupiravir (Antiviral Drug for Treatment of COVID-19) in Lung, Liver, Heart, and Kidney Tissues in Rats

Dose-dependent Oxidative Damage of Molnupiravir (Antiviral Drug for Treatment of COVID-19) in Lung, Liver, Heart, and Kidney Tissues in Rats

Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries

Recent progress in neonatal hyperoxic lung injury

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