“…Despite the proven efficacy of radiotherapy, the application is limited due to undesired effects such as neurocognitive disabilities, endocrinological disturbances, de novo tumor formation and malignant transformation [10, 14, 26, 27]. Therefore, some authors focus on chemotherapy as first-choice therapy, independent of the patient age, to delay radiotherapy when tumor progression or LMD occurs [1, 2, 13,28,29,30,31,32,33]. …”