Does caffeine modify corticomotor excitability?

Cerqueira, Vitor Barbosa; Mendonça, Alexandre de; Minez, A.; Dias, Ana Rita Abrantes; Carvalho, Mamede de

doi:10.1016/j.neucli.2006.08.005

Cited by 50 publications

(60 citation statements)

References 33 publications

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“…However, applying an intensity of 10% above threshold, we observed a consistent and statistically significant decrease in the CSP (between 12-16%) in different upper limb muscles [18]. Although this phenomenon merits further research, we hypothesized that the inhibition of adenosine A 2A receptors could activate D2-dopamine striatal receptors, decreasing the activity of the GABAergic enkephalinergic striatopallidal neurons of the indirect pathway [18].…”

Section: Upper Motor Neuronmentioning

confidence: 56%

“…However, another study detected significantly increased LMN excitability in 7 healthy controls after caffeine administration (6 mg/kg) by investigating the H-reflex stimulusresponse curve [17]. Another approach is to explore F-wave amplitude and peripheral silent period to assess LMN excitability; however, in a healthy control population we did not find any change in those measurements after the ingestion of 200 mg of caffeine [18].…”

Section: Lower Motor Neuronmentioning

confidence: 64%

“…Caffeine intake decreases CSP following TMS with intensity 10% above cortico-motor threshold [18]. Physiologically, CSP is significantly increased in the target muscle after fatiguing contraction [24,37].…”

Section: Aimmentioning

confidence: 96%

“…The accumulated experience shows that caffeine does not change motor-evoked amplitude (MEP), central conduction time or corticomotor threshold [18,19,22].…”

Section: Upper Motor Neuronmentioning

confidence: 99%

“…A structured questionnaire was applied to all subjects, in order to appraise socio-demographic characteristics and medical history, as well as caffeine exposure, alcohol consumption and smoking habits [18]. The inclusion criterion was age between 20 and 40 years, and no or moderate caffeine ingestion.…”

Section: Populationmentioning

confidence: 99%

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Electrophysiological Studies in Healthy Subjects Involving Caffeine

Carvalho

Marcelino

2010

JAD

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Abstract. We review the electrophysiological studies concerning the effects of caffeine on muscle, lower and upper motor neuron excitability and cognition. Several different methods have been used, such as electromyography, recruitment analysis, H-reflex, transcranial magnetic stimulation (TMS), electroencephalography and event-related potentials. The positive effect of caffeine on vigilance, attention, speed of reaction, information processing and arousal is supported by a number of electrophysiological studies. The evidence in favor of an increased muscle fiber resistance is not definitive, but higher or lower motor neuron excitability can occur as a consequence of a greater excitation of the descending input from the brainstem and upper motor neurons. TMS can address the influence of caffeine on the upper motor neuron. Previous studies showed that cortico-motor threshold and intracortical excitatory and inhibitory pathways are not influenced by caffeine. Nonetheless, our results indicate that cortical silent period (CSP) is reduced in resting muscles after caffeine consumption, when stimulating the motor cortex with intensities slightly above threshold. We present new data demonstrating that this effect is also observed in fatigued muscle. We conclude that CSP can be considered a surrogate marker of the effect of caffeine in the brain, in particular of its central ergogenic effect.

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Section: Upper Motor Neuronmentioning

confidence: 56%

Section: Lower Motor Neuronmentioning

confidence: 64%

Section: Aimmentioning

confidence: 96%

“…The accumulated experience shows that caffeine does not change motor-evoked amplitude (MEP), central conduction time or corticomotor threshold [18,19,22].…”

Section: Upper Motor Neuronmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

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Electrophysiological Studies in Healthy Subjects Involving Caffeine

Carvalho

Marcelino

2010

JAD

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Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: A six‐month longitudinal study

Carvalho

Swash

2009

Muscle and Nerve

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By following a group of amyotrophic lateral sclerosis (ALS) patients longitudinally using lower motor neuron (LMN) and upper motor neuron (UMN) markers of dysfunction it may be possible to better understand the functional relationships between these motor systems in this disease. We used neurophysiological techniques to follow UMN and LMN dysfunction in a group of 28 patients with ALS, in comparison with the ALS functional rating scale (ALS-FRS) score and the forced vital capacity (FVC). We used motor unit number estimation (MUNE), compound muscle action potential (CMAP) amplitude, and the Neurophysiological Index (NI) to quantify the LMN disorder, and transcranial motor stimulation to study cortical motor threshold, motor-evoked response amplitude, central motor conduction time, and cortical silent period (CSP). The patients were studied shortly after diagnosis and then 6 months later, using both abductor digiti minimi muscles (ADM); ADM strength was initially >MRC 3 (Medical Research Council, UK). The NI and MUNE changed more than any other variable. CSP increased by about 30%, a change more marked than the slight increase observed in the cortical motor threshold (9%). The normal increase of CSP after acute muscle fatigue was preserved during disease progression. The CSP increase correlated with the MUNE rate of decay but not to the NI reduction, perhaps because NI includes F-wave frequency in itscalculation. There was no definite correlation between UMN and LMNdysfunction or progression, but there was a link between CSP and LMN changes in ALS. The CSP may be a useful variable in following UMN dysfunction in clinical practice and in clinical trials.

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Caffeine and cortical excitability, as measured with paired‐pulse transcranial magnetic stimulation

Strunge,

Bostock,

Howells

et al. 2023

Muscle and Nerve

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Introduction/AimsThe transcranial magnetic stimulation tests of short‐interval intracortical inhibition (SICI) by both conventional amplitude measurements (A‐SICI) and threshold‐tracking (T‐SICI) are important methods to investigate intracortical inhibitory circuits, and T‐SICI has been proposed to aid the diagnosis of amyotrophic lateral sclerosis. Beverages containing caffeine are widely consumed, and caffeine has been reported to affect cortical excitability. The aim of this study was to determine whether these SICI tests are affected by caffeine.MethodsTwenty‐four healthy subjects (13 females, 11 males, aged from 19 to 31, mean: 26.2 ± 2.4 years) were studied in a single fixed‐dose randomized double‐blind placebo‐controlled cross‐over trial of 200 mg caffeine or placebo ingested as chewing gum. A‐SICI and T‐SICI, using parallel tracking (T‐SICIp), were performed before and after chewing gum.ResultsThere was no significant change in SICI parameters after placebo in A‐SICI (p > .10) or T‐SICIp (p > .30), and no significant effect of caffeine was found on A‐SICI (p > .10) or T‐SICIp (p > .50) for any of the interstimulus intervals.DiscussionThere is no need for caffeine abstention before measurements of SICI by either the T‐SICI or A‐SICI measurements.

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Does caffeine modify corticomotor excitability?

Cited by 50 publications

References 33 publications

Electrophysiological Studies in Healthy Subjects Involving Caffeine

Electrophysiological Studies in Healthy Subjects Involving Caffeine

Sensitivity of electrophysiological tests for upper and lower motor neuron dysfunction in ALS: A six‐month longitudinal study

Caffeine and cortical excitability, as measured with paired‐pulse transcranial magnetic stimulation

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