Does caffeine induce dominant lethal mutations in mice?

Adler, I.‐D.

doi:10.1007/bf00287078

Cited by 23 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1968;Rohrborn 1968;Adler 1969;Epstein 1970). However, further experimental insight into the role of irreparable damage to the genetic material and the related genetic consequences is obviously needed.…”

Section: Discussionmentioning

confidence: 99%

Chromosome Aberrations Induced in Cultured Human Cells by Caffeine

Lee

1971

The Japanese journal of genetics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Chromosome Aberrations Induced in Cultured Human Cells by Caffeine

Lee

1971

The Japanese journal of genetics

View full text Add to dashboard Cite

show abstract

“…Isolated treatment of mouse testes in a saturated solution of caffeine led to clumping and fragmentation of chromosomes (Slizynski 1971). With large dose administration of caffeine (250 mg per kg), the fertility of male mice is initially decreased (Cattanach 1962;Adler 1969). At a caffeine dosage level of 300 mg per day, there is a significant reduction in the fertility of chronically treated male rats (Kuhlmann et al 1968).…”

Section: Teratogenicitymentioning

confidence: 99%

The Pharmacology and Toxicology of Caffeine

Lachance

1982

Journal of Food Safety

View full text Add to dashboard Cite

The widespread use of caffeine is most commonly linked to the stimulatory action it has on the central nervous system. Generally, adverse effects include gastrorrhea, insomnia, and diuresis. Tolerance and withdrawal symptoms have been observed and excessive consumption can lead to an anxiety neurosis condition (caffeinism). The actions of caffeine may involve its effects on neurotransmitter turnover and metabolism; its promotion of the cellular messenger, cAMP; its sensitization of the calcium releasing mechanisms of cellular reticulum; or its antagonism of the autacoid, adenosine. Caffeine lethality is rare in man but caffeine poisoning with its gastrointestinal, CNS, and cardiovascular stimulation could especially be hazardous to children. Most of the mutagenicity work has been performed in organisms whose cellular DNA synthesis and repair mechanism vary significantly from those found in man. The work in human cell lines suggests that caffeine‐induced chromosomal breakage, with its lack of chromatid exchange would promote cell lethality, not muta‐genticity. Nothing but circumstantial evidence implicates caffeine as a human carcinogen or teratogen. Involvement of caffeine as a cocarcinogen or a coteratogen (which includes effects on gamete production or fetal development) appears far more likely, but neither has even begun to be truly evaluated. Basic metabolism of caffeine involves the processes of N‐demethylation, hydration, and oxidation; and most likely requires the cytochrome P1‐450 system. Though various metabolites of caffeine are pharmacologically active, the extent of involvement of individual metabolites in the pharmacological or toxicological responses of caffeine in man is still unknown.

show abstract

“…Linkage map, 11 Lipopolysaccharide, 274, 280 Litter size, 547, 554 Liver, [89][90][91]94,99,108,122,140,418 poison,577 LSD,575 Lung,94 Lymphocyte,380,[525][526][527]416,420,421 Ly~~ 12~ 15~ 175,196,197,229,291 immunity to,238 Lysogeny,21,20,122,152,196,197,231 Macrophage,401,402 Magdala red,293,305 Magnesium acetate,123 Magnesium ions,123 Magnesium sulfate,208 Maize, see Corn MAK, see Methylated serum albumin kieselguhr column Malate dehydrogenase, 603 lix Maleic hydrazide (MH), 45,61,359,360,378,493,494,495,498,560 MAM,…”

Section: Chaptermentioning

confidence: 99%

Chemical Mutagens

1971

View full text Add to dashboard Cite

Does caffeine induce dominant lethal mutations in mice?

Cited by 23 publications

References 34 publications

Chromosome Aberrations Induced in Cultured Human Cells by Caffeine

Chromosome Aberrations Induced in Cultured Human Cells by Caffeine

The Pharmacology and Toxicology of Caffeine

Chemical Mutagens

Contact Info

Product

Resources

About