Does Breast Feeding Protect Against the Development of Clinical Symptoms of Celiac Disease in Children?

Auricchio, Salvatore; Follo, Daniela; G, De Ritis; Giunta, Anna; Marzorati, D.; Prampolini, L; Ansaldi, N; Levi, Paul; Dall’Olio, Daniele; Bossi, Anna

doi:10.1097/00005176-198302030-00006

Cited by 117 publications

(86 citation statements)

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“…Hazard ratio at 5 yr, 0.7 (95% CI, 0. observational, retrospective studies, [26][27][28][29] which were summarized in a meta-analysis 30 and a systematic review. 31 These surveys did not clarify whether breast-feeding provides permanent protection against celiac disease or simply delays the onset of symptoms.…”

Section: Years Of Agementioning

confidence: 99%

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Lionetti¹,

et al. 2014

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Section: Years Of Agementioning

confidence: 99%

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Lionetti¹,

et al. 2014

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“…However, randomized trials are lacking and with few exceptions [28,39,41], existing studies have been based on retrospectively collected data [42,43,44,45,46,47]. The largest case-control study so far is that by Ivarsson et al [46], where the authors found a reduced risk of future CD in children aged 0–1.9 years at diagnosis but not in children aged 2.0–14.9 years at diagnosis.…”

Section: Breastfeedingmentioning

confidence: 99%

Timing of Introduction of Gluten and Celiac Disease Risk

Ludvigsson¹,

Fasano²

2012

Ann Nutr Metab

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Breast milk is the natural nutrition for infants, but in the second half of the first year of life, complementary feeding is needed. Many complementary foods contain gluten, but gluten exposure is associated with the risk of developing celiac disease (CD). CD is a disease with considerable morbidity and mortality. Although CD is associated with certain genetic features, carrying the human leukocyte antigen haplotypes DQ2 or DQ8 (a prerequisite for CD development) cannot fully explain who will or who will not develop CD. Potential risk factors for CD include perinatal events and infant feeding practice. With the exception that children who are breastfed at and beyond gluten introduction into the diet probably may be at a lower risk of developing CD, and that heavy gluten load early in life may increase the risk of future CD, data on the impact of infant feeding are inconsistent.

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“…Greco et al compared children breast fed for at least 90 days with children breast fed for more than 90 days, 22 Peters et al compared children breast fed for more than 2 months with those breast fed for less than 2 months, 4 and Auricchio et al compared children breast fed for more than 30 days with those breast fed for less than 30 days. 5 Falth-Magnusson et al 23 and Ascher et al 6 compared the median time of both exclusive and partial breast feeding in cases and controls. Thus because of the use of different ways of assessing the duration of breast feeding, we considered it inappropriate to combine the data on this variable statistically into a single pooled effect.…”

Section: Duration Of Breast Feedingmentioning

confidence: 99%

Effect of Breast-Feeding on Risk of Coeliac Disease: A Systematic Review and Meta-Analysis of Observational Studies

Ak¹,

Ramanan²,

Basude³

2005

Journal of Pediatric Gastroenterology and Nutrition

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Background: Coeliac disease (CD) is a disorder that may depend on genetic, immunological, and environmental factors. Recent observational studies suggest that breast feeding may prevent the development of CD. Aim: To evaluate articles that compared effects of breast feeding on risk of CD. Methods: Systematic review and meta-analysis of observational studies published between 1966 and June 2004 that examined the association between breast feeding and the development of CD. Results: Six case-control studies met the inclusion criteria. With the exception of one small study, all the included studies found an association between increasing duration of breast feeding and decreased risk of developing CD. Meta-analysis showed that the risk of CD was significantly reduced in infants who were breast feeding at the time of gluten introduction (pooled odds ratio 0.48, 95% CI 0.40 to 0.59) compared with infants who were not breast feeding during this period. Conclusions: Breast feeding may offer protection against the development of CD. Breast feeding during the introduction of dietary gluten, and increasing duration of breast feeding were associated with reduced risk of developing CD. It is, however, not clear from the primary studies whether breast feeding delays the onset of symptoms or provides a permanent protection against the disease. Long term prospective cohort studies are required to investigate further the relation between breast feeding and CD.

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Does Breast Feeding Protect Against the Development of Clinical Symptoms of Celiac Disease in Children?

Cited by 117 publications

References 0 publications

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Timing of Introduction of Gluten and Celiac Disease Risk

Effect of Breast-Feeding on Risk of Coeliac Disease: A Systematic Review and Meta-Analysis of Observational Studies

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