Does botulinum therapy affect the urine microbiome of patients with neurogenic bladder? Metagenomic sequencing results

Филиппова, Е. С.; Баженов, И. В.; Зырянов, А. В.

doi:10.21886/2308-6424-2020-8-3-85-96

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…All the urine studies had moderate risk of bias. The studies did not account for confounding variables and the extent of injury in the study populations were not sufficiently described [23][24][25][26][27][28] (Supplementary Table 1).…”

Section: Spinal Cord Injury and Urinary Tract Microbiomementioning

confidence: 99%

“…Their longitudinal analysis showed that the microbiome changed with the onset of probiotics or the presence of symptomatic UTI but reverts to baseline microbiome profile. Philippova et al [26] studied the effect of intradetrusor botulinum in 6 adults (2 males, 4 females) with SCI from trauma or spina bifida. The intervention decreased the occurrence of symptomatic UTI after 6 months of observation.…”

Section: Spinal Cord Injury and Urinary Tract Microbiomementioning

confidence: 99%

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Systematic review of the changes in the microbiome following spinal cord injury: animal and human evidence

et al. 2022

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Study design Systematic review. Objectives To investigate the changes in the microbiome among human and animal populations with spinal cord injury (SCI). Methods Four databases (EMBASE, Medline (Ovid), Web of Science, Cochrane Central Register of Trials (CENTRAL)) and Google Scholar were searched. No language restrictions were applied. Data extraction was done in parallel and independently by two reviewers. The search was last conducted on 07 April 2021. Results There were 6869 studies retrieved, 43 full-text studies reviewed, and 19 studies included. There were seven animal gut studies, six human gut studies, and six urinary tract studies identified. There were no publications found on other body sites. Among the included studies, we observed a consistent and significant difference in gut microbiome composition between populations with SCI and able-bodied populations. This is characterized by a decrease in beneficial butyrate-producing bacteria (Faecalbacterium, Megamonas, Roseburia) and an increase in inflammation-associated bacteria (Alistipes, Anaerotruncus, and Lachnoclostridium). On the other hand, the urine of individuals with SCI was polymicrobial and members of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae) were frequently observed. Probiotics were shown to induce a significant but transient shift in the urinary tract microbiome. The studies had low to moderate risks of bias. Conclusions There are limited studies on the changes in microbiome among SCI populations. The gut microbiome was characterized by bacterial profiles associated with chronic inflammation and metabolic disorder while the studies of the urinary tract microbiome show the dominance of bacterial genera associated with urinary tract infection.

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Section: Spinal Cord Injury and Urinary Tract Microbiomementioning

confidence: 99%

Section: Spinal Cord Injury and Urinary Tract Microbiomementioning

confidence: 99%

Systematic review of the changes in the microbiome following spinal cord injury: animal and human evidence

et al. 2022

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Urinary tract microbiota in patients with multiple sclerosis and neurogenic pelvic dysfunction

Luzanova,

Karpova,

Abramovskikh

et al. 2024

Bûll. sib. med.

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Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system common among young people. Neurogenic bladder often is a common symptom of the disease. Young people with MS often have to make treatment and family planning decisions at the same time. The possibility of realizing reproductive plans is closely related to urological complications of the disease, high risk of urinary tract infections, and sexual dysfunction. In addition, disease modifying therapies for MS play a significant role in increasing the likelihood of infectious complications. Therefore, the issue of infection prevention in MS is critical. Effective personalized prevention of urogenital infections is possible with a clear understanding of the microbiota composition. DNA sequencing methods have changed the conventional idea that normal urine is sterile and gave rise to the concepts of asymptomatic bacteriuria in healthy people. Moreover, data on the genitourobiome of patients with neurological diseases have recently emerged. Extended knowledge about the microbiology in the genitourinary system of neurological patients is necessary to unleash the capacity of health-preserving technologies. The aim of the review was to integrate currently available data concerning the microbiocenosis of the lower urinary tract and vagina with underlying neurogenic pelvic dysfunction, including MS, as well as to present data on the association between closely located biotopes and the effect of MS therapy on the risks of developing genitourinary infections.

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Does botulinum therapy affect the urine microbiome of patients with neurogenic bladder? Metagenomic sequencing results

Cited by 2 publications

References 26 publications

Systematic review of the changes in the microbiome following spinal cord injury: animal and human evidence

Systematic review of the changes in the microbiome following spinal cord injury: animal and human evidence

Urinary tract microbiota in patients with multiple sclerosis and neurogenic pelvic dysfunction

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