Does bone mobilization interfere with energy metabolism in transition cows?

Matthaei, M.O.; Kononov, S.U.; Rehage, J.; Szura, G.; Leiter, I.; Hansen, Kirstin Anderson; Daenicke, S.; Soosten, Dirk von; Kersten, Susanne; Meyer, Ulrich; Wilkens, Mirja R.

doi:10.3168/jdsc.2022-0239

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…The age-related decrease in ucOC was less significant than that in cOC. The concentration of ucOC in postpartum multiparous cows (Figure 1D) could be explained by the low ucOC levels and low insulin sensitivity in postpartum cows (49). In addition, the changes in cOC or ucOC levels between BW-1 and BW1 and the different postpartum levels between CON and KET suggest that both cOC and ucOC are involved in energy metabolism related to postpartum ketosis.…”

Section: Discussionmentioning

confidence: 97%

Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates

Choi

Choe

et al. 2023

Front. Vet. Sci.

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IntroductionKetosis is a predominant metabolic problem and a risk factor for several postpartum diseases. This retrospective study aimed to evaluate the complete blood count (CBC), plasma biochemistry, and osteocalcin and identify significant prepartum and early postpartum values expressed in ketotic cows.MethodsIn 135 Holstein Friesian cows, 210 parturitions of 114 primiparous and 96 multiparous cows were examined. According to the plasma concentrations of β-hydroxybutyrate (BHB; ≥ 1.4 mmol/L) or non-esterified fatty acids (NEFA; ≥ 0.7 mmol/L) in the postpartum period, cows were divided into healthy cows (CON) and ketotic cows (KET). Analyses of CBC and biochemistry profiles were performed from −6 to 4 weeks of parturition every 2 weeks (prepartum; BW–5, BW–3, and BW–1, postpartum; BW1 and BW3), and osteocalcin ELISA tests were performed using blood samples from −2 to 2 weeks of parturition (BW–1 and BW1).ResultsIn primiparous KET (n = 114) before parturition, lower lymphocyte (Lym) in BW–5 and BW–3, lower red blood cell (RBC) in BW–5, higher mean corpuscular volume (MCV) in BW–1, and higher NEFA in BW–3 were significant compared with CON. Primiparous KET showed lower carboxylated osteocalcin (cOC) levels and a significant decrease after parturition. In multiparous KET (n = 96) before parturition, lower neutrophil (Neu) in BW–5, higher hemoglobin (HGB) in BW–5, higher MCV in BW–5 and BW–1, higher MCH in BW–5, lower total cholesterol (TC) in BW–5, higher triglyceride (TG) in BW–3, higher NEFA in BW–1, higher glucose (Glu) in BW–3, lower γ-glutamyl transferase (GGT) in BW–5, lower inorganic phosphate (iP) in BW–3, and higher body condition score (BCS) in BW–5 and BW–3 were significant compared with CON. Multiparous KET showed decreased cOC and uncarboxylated osteocalcin (ucOC) after parturition, which was lower than that in the CON group.DiscussionThe blood parameters expressing different values between CON and KET in prepartum or early postpartum periods are presumed to show individual nutrition and health states, liver function, and overweight status. These parameters could be valuable indicators that can be used to prevent the occurrence of ketosis and improve management practices by recognizing these differences in ketotic cows before calving.

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Section: Discussionmentioning

confidence: 97%

Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates

Choi

Choe

et al. 2023

Front. Vet. Sci.

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“…Reference values for bone markers in dogs, in relation to their age [44] and breed [48], are reported in the literature. Bone metabolism markers have been studied in metabolic bone diseases [49], osteomyelitis [50], bone tumours [51], and various experimental fracture models and bone defects [52].…”

Section: Introductionmentioning

confidence: 99%

Effects of Erythropoietin-Promoted Fracture Healing on Bone Turnover Markers in Cats

Vasileva,

Chaprazov,

Milanova

2024

JFB

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In orthopaedics, erythropoietin (EPO) is applied in the preoperative management of anaemic patients, but also as a stimulating factor to assist bone regeneration due to its angiogenic and osteoinductive potential. Since orthopaedists mainly rely on their clinical experience to assess bone healing, additional and more objective methods such as studying the dynamics of bone markers are needed. Therefore, the aim of this study was to investigate the plasma activity of bone-specific alkaline phosphatase (BALP), the N-terminal propeptide of type I collagen (PINP), the C-terminal telopeptide of type I collagen (CTX), and deoxypyridinoline (DPD) during the first 2 months of healing of comminuted fractures in cats, either non-stimulated or locally stimulated with recombinant human erythropoietin (rhEPO). The study included twelve cats of mixed breeds, aged 7.2 ± 4 months, weighing 2.11 ± 1.1 kg, with comminuted diaphyseal fractures of the femur. Surgical treatment with plate osteosynthesis was performed in all animals. The cats were randomly divided into two groups—a control (n = 6) and an EPO group (n = 6). The locally applied EPO leads to the increased activity of bone formation markers (BALP and PINP) during the second week after the osteosynthesis, preceding the peaks in the control group by two weeks. The studied bone resorption markers (DPD, CTX) varied insignificantly during the studied period. In conclusion, erythropoietin could serve as a promoter of bone healing in comminuted fractures in cats.

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Does bone mobilization interfere with energy metabolism in transition cows?

Cited by 2 publications

References 31 publications

Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates

Comparison of prepartum blood parameters in dairy cows with postpartum ketosis and new risk prediction candidates

Effects of Erythropoietin-Promoted Fracture Healing on Bone Turnover Markers in Cats

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