Does Beta-blocker Therapy Improve the Survival of Patients with Metastatic Non-small Cell Lung Cancer?

Aydıner, Adnan; Çiftçi, Rümeysa; Karabulut, Senem; Kılıç, Leyla

doi:10.7314/apjcp.2013.14.10.6109

Cited by 37 publications

(37 citation statements)

References 29 publications

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“…Lung cancers rank the top of cancer-related death with increasing morbidity around the world (Aydiner et al, 2013;Cai et al, 2013;Kaya et al, 2013;Mutlu et al, 2013;Natukula et al, 2013;Oven et al, 2013;Unal et al, 2013;Wang et al, 2013). At present, the chemotherapeutic protocols for NSCLC mainly apply platinums as basic drugs combining with the third generation chemotherapeutic drugs such as paclitaxel, gemcitabine and vinorelbine, etc..…”

Section: Discussionmentioning

confidence: 99%

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

Qiu¹,

Zhao²

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

Qiu¹,

Zhao²

2014

Asian Pacific Journal of Cancer Prevention

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“…NSCLC patients take up 80%~85% of total cases in lung cancer (Mutlu et al, 2013;Oven et al, 2013;Aydiner et al, 2013;Cai et al, 2013;Kaya et al, 2013;Natukula et al, 2013;Unal et al, 2013;Wang et al, 2013) and patients with locally advanced NSCLC who can't receive surgery were mainly treated with radiotherapy, the effect of which was mainly marked with dose-dependence. Although highdose radiotherapy can improve the remission rate and local control rate, at the same time, it can bring about severe side effects, such as severe radiation esophagitis and radiation pneumonitis (Feng et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Radiosensitization Effect of Overexpression of Adenovirus-mediated SIRT6 on A549 Non-small Cell Lung Cancer Cells

Cai¹,

Sheng²,

Shixiong³

2014

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the radiosensitization effect of overexpression of silent information regulator 6 (SIRT6) on A549 non-small cell lung cancer (NSCLC) cells. Methods: Adenovirus vector Ad-SIRT6 causing overexpression of SIRT6 was established. Western blotting and MTT assay were adopted to detect the level of SIRT6 protein and the inhibitory rate of A549 cell proliferation after different concentrations of adenovirus transduction (0, 25, 100, 200, and 400 pfu/cell) for 24 h. Control group, Ad-null group and Ad-SIRT6 group were designed in this experiment and virus concentration of the latter two groups was 200 pfu/cell. Colony formation assays were employed to test survival fraction (SF) of the 3 groups after 0, 2, 4, 6, 8, 10 X-ray irradiation. Flow cytometry was used to detect the status of cell cycle of 3 groups after 48 h of 4Gy X-ray irradiation and Western blotting was used to determine the expression of apoptosis-related genes of 3 groups after 48 h of 4GyX-ray irradiation. Results: In the range of 25~400 pfu/cell, the inhibitory rate of A549 cell proliferation increased as adenovirus concentration raised. The inhibitory rates under the concentrations of 0, 25, 100, 200, and 400 pfu/cell were 0%, 4.23±0.34%, 12.7±2.57%, 22.6±3.38%, 32.2±3.22%, 38.7±4.09% and 47.8±5.58% and there were significantly differences among groups (P<0.05). SF in Ad-SIRT6 group was lower than Ad-null and control groups after 4~10Gy X-ray irradiation (P<0.05) and the sensitization enhancement ratio (SER) was 1.35 when compared with control group. Moreover, after 48 h of 4Gy X-ray irradiation, there appeared a significant increase in G1-phase cell proportion, up-regulated expression of the level of apoptosis-promoting genes (Bax and Cleaved caspase-3), but a obvious decline in S-phase and G2-phase cell proportion and a significant decrease of the level of apoptosisinhibiting gene (Bal-2) in the Ad-SIRT6 group (P<0.05). Conclusion: The over-expression of adenovirus-mediated SIRT6, which has radiosensitization effect on A549 cells of NSCLC, can inhibit the proliferation of A549 cells and cause G0/G1 phase retardation as well as induce apoptosis of cells.

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“…Lung cancer is a common malignant tumor in China, and NSCLC patients take up 80%~85% of total cases in lung cancer (Aydiner et al, 2013;Cai et al, 2013;Kaya et al, 2013;Mutlu et al, 2013;Natukula et al, 2013;Oven et al, 2013;Unal et al, 2013;Wang et al, 2013). How to effectively treat patients with lung cancer is a focus in clinical settings (Yan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Experimental Study on Inhibition Effects of the XAF1 Gene against Lung Cancer Cell Proliferation

Yang

Chen²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Does Beta-blocker Therapy Improve the Survival of Patients with Metastatic Non-small Cell Lung Cancer?

Cited by 37 publications

References 29 publications

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

Expression of ERCC1, RRM1 and LRP in Non-small Cell Lung Cancers and their Influence on Chemotherapeutic Efficacy of Gemcitabine Concomitant with Nedaplatin

Radiosensitization Effect of Overexpression of Adenovirus-mediated SIRT6 on A549 Non-small Cell Lung Cancer Cells

Experimental Study on Inhibition Effects of the XAF1 Gene against Lung Cancer Cell Proliferation

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