Does Assessment of Cervical Phosphorylated Insulin-like Growth Factor Binding Protein-1 by Bedside Vaginal Swab Test Really Predict Preterm Birth?

Couka, Laura Tenoudji-Cohen; Donato, Xavier-Côme; Glowaczower, E; Squercioni-Aumont, Anne; Katsogiannou, Maria; Desbrière, Raoul

doi:10.1007/s43032-020-00432-y

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Blue-colored bands on the test and control lines indicate a positive and valid test [130]. The device's claimed sensitivity, specificity, NPV, PPV, and diagnostic efficiency are 60, 67.7, 23, 91.3, and 66%, respectively, with an LOD of 10 ng/mL [131].…”

Section: Actim ® Partusmentioning

confidence: 99%

Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor

Gondane,

Kumbhakarn,

Maity

et al. 2024

Bioengineering

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Preterm birth (PTB) is the primary cause of neonatal mortality and long-term disabilities. The unknown mechanism behind PTB makes diagnosis difficult, yet early detection is necessary for controlling and averting related consequences. The primary focus of this work is to provide an overview of the known risk factors associated with preterm labor and the conventional and advanced procedures for early detection of PTB, including multi-omics and artificial intelligence/machine learning (AI/ML)- based approaches. It also discusses the principles of detecting various proteomic biomarkers based on lateral flow immunoassay and microfluidic chips, along with the commercially available point-of-care testing (POCT) devices and associated challenges. After briefing the therapeutic and preventive measures of PTB, this review summarizes with an outlook.

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Section: Actim ® Partusmentioning

confidence: 99%

Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor

Gondane,

Kumbhakarn,

Maity

et al. 2024

Bioengineering

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“…The role of IGFBP-1 and PAPP-A2 in the prediction of PTD and other obstetrical complications has been the subject of previous reports. For example, bedside tests detecting IGFBP-1 (or PAMG-1) in the cervicovaginal fluid are available to predict PTD in women presenting with symptoms of spontaneous preterm labor [83][84][85][86][87][88][89]. Moreover, IGFBP-1 (or PAMG-1) in the cervicovaginal fluid has been proposed as a test for ruptured membranes [90][91][92][93][94].…”

Section: Higher Expression Of Igfbp-1 and Papp-a2 Inmentioning

confidence: 99%

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

Prasad¹,

Romero²,

Chaiworapongsa³

et al. 2023

Fetal Diagn Ther

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Introduction: Approximately 47% of women with an episode of preterm labor deliver at term; however, their infants are at greater risk of being small for gestational age and for neurodevelopmental disorders. In these cases, a pathologic insult may disrupt the homeostatic responses sustaining pregnancy. We tested the hypothesis of an involvement of components of the insulin-like growth factor (IGF) system. Methods: This is a cross-sectional study in which maternal plasma concentrations of pregnancy-associated plasma protease (PAPP)-A, PAPP-A2, insulin-like growth factor-binding protein 1 (IGFBP-1), and IGFBP-4 were determined in the following groups of women: (1) no episodes of preterm labor, term delivery (controls, n = 100); (2) episode of preterm labor, term delivery (n = 50); (3) episode of preterm labor, preterm delivery (n = 100); (4) pregnant women at term not in labor (n = 61); and (5) pregnant women at term in labor (n = 61). Pairwise differences in maternal plasma concentrations of PAPP-A, PAPP-A2, IGFBP-1, and IGFBP-4 among study groups were assessed by fitting linear models on log-transformed data and included adjustment for relevant covariates. Significance of the group coefficient in the linear models was assessed via t-scores, with p < 0.05 deemed a significant result. Results: Compared to controls, (1) women with an episode of premature labor, regardless of a preterm or a term delivery, had higher mean plasma concentrations of PAPP-A2 and IGFBP-1 (each p < 0.05); (2) women with an episode of premature labor who delivered at term also had a higher mean concentration of PAPP-A (p < 0.05); and (3) acute histologic chorioamnionitis and spontaneous labor at term were not associated with significant changes in these analytes. Conclusion: An episode of preterm labor involves the IGF system, supporting the view that the premature activation of parturition is a pathologic state, even in those women who delivered at term.

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Does Assessment of Cervical Phosphorylated Insulin-like Growth Factor Binding Protein-1 by Bedside Vaginal Swab Test Really Predict Preterm Birth?

Cited by 2 publications

References 29 publications

Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor

Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor

Further Evidence that an Episode of Premature Labor Is a Pathologic State: Involvement of the Insulin-Like Growth Factor System

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