Does aspirin exist in polymorphic states?

Schwartzman, George

doi:10.1111/j.2042-7158.1972.tb08957.x

Cited by 28 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 However, such findings were not substantiated because of insufficient physical data and a lack of any X-ray diffraction evidence. [6][7][8][9] Other studies have indeed illustrated that the differences observed in the dissolution velocities of aspirin recrystallized from different solvents may be due to the extent of expression of different crystal planes. 3,4,10 Dissolution studies of different aspirin crystal planes have revealed a dissolution rate at least 50% larger for crystal plane (100) compared with that for crystal plane (001).…”

mentioning

confidence: 96%

Surface Characterization of Aspirin Crystal Planes by Dynamic Chemical Force Microscopy

et al. 2000

View full text Add to dashboard Cite

Tapping mode (TM) atomic force microscopy (AFM) has been applied in a novel fashion to characterize and distinguish the (001) and (100) surfaces of individual aspirin crystals. The surface characterization was achieved by amplitude-phase, distance (a-p,d) measurements employing gold-coated AFM probes functionalized with self-assembled monolayers (SAM). Experiments using model probes coated with -CH3 and -COOH terminated SAMs have been performed on the two aspirin crystal planes (001) and (100). Results indicate that the hydrophobic -CH3 terminated AFM probes had a greater degree of interaction with the crystal plane (001), whereas the -COOH terminated AFM probes had a larger interaction with the crystal plane (100). Interpretation of these data, based upon the chemistries of the probes, correlates with current understanding of the crystal surface chemistry derived from X-ray diffraction data and dissolution rate studies.

show abstract

mentioning

confidence: 96%

Surface Characterization of Aspirin Crystal Planes by Dynamic Chemical Force Microscopy

et al. 2000

View full text Add to dashboard Cite

show abstract

“…However, these studies were inconclusive. In the end, differences in physical properties were attributed to salicylic acid impurities …”

mentioning

confidence: 99%

The Predictably Elusive Form II of Aspirin

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The recently discovered new polymorph of aspirin, form II,1 has ended a long‐awaited speculation of the possible polymorphism of aspirin 2–10. The finding, once again, echoes the remark made by McCrone about 40 years ago that finding a new crystal form is a matter of time and effort 11…”

Section: Introductionmentioning

confidence: 56%

Understanding the Polymorphism of Aspirin with Electronic Calculations

2007

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Does aspirin exist in polymorphic states?

Cited by 28 publications

References 4 publications

Surface Characterization of Aspirin Crystal Planes by Dynamic Chemical Force Microscopy

Surface Characterization of Aspirin Crystal Planes by Dynamic Chemical Force Microscopy

The Predictably Elusive Form II of Aspirin

Understanding the Polymorphism of Aspirin with Electronic Calculations

Contact Info

Product

Resources

About