Abstract:Aprotinin has been reported to influence positively or negatively the process of ischaemia-reperfusion. However, it is a complex drug acting on platelets, neutrophils and coagulation, which may also have a direct effect by inhibiting intracellular proteases and free radical generation. The goal of this study was to determine the direct effects of aprotinin on the myocardial performances of an isolated blood perfused rabbit heart preparation after normothermic global ischaemia. Two groups of 10 hearts were stud… Show more
“…It has been suggested that the cardioprotective effect of aprotinin may derive from antiinflammatory properties and/or direct effect of aprotinin on the myocardium. 1,6,23 Patients undergoing OPCAB with poor myocardial function may get more benefit from aprotinin besides the hemostatic effect. Procoagulant activity after OPCAB has been reported with biochemical terms.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism underlying the cardioprotective effect of aprotinin is unclear. It has been suggested that the cardioprotective effect of aprotinin may derive from anti‐inflammatory properties and/or direct effect of aprotinin on the myocardium 1,6,23. Patients undergoing OPCAB with poor myocardial function may get more benefit from aprotinin besides the hemostatic effect.…”
“…It has been suggested that the cardioprotective effect of aprotinin may derive from antiinflammatory properties and/or direct effect of aprotinin on the myocardium. 1,6,23 Patients undergoing OPCAB with poor myocardial function may get more benefit from aprotinin besides the hemostatic effect. Procoagulant activity after OPCAB has been reported with biochemical terms.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism underlying the cardioprotective effect of aprotinin is unclear. It has been suggested that the cardioprotective effect of aprotinin may derive from anti‐inflammatory properties and/or direct effect of aprotinin on the myocardium 1,6,23. Patients undergoing OPCAB with poor myocardial function may get more benefit from aprotinin besides the hemostatic effect.…”
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