Does Allergen-specific Immunotherapy Induce Contact Allergy to Aluminium?

Netterlid, Eva; Hindsén, Monica; Siemund, Ingrid; Björk, Jonas; Werner, Sonja; Jacobsson, Helene; Güner, Nuray; Bruze, M.

doi:10.2340/00015555-1409

Cited by 29 publications

(36 citation statements)

References 25 publications

(22 reference statements)

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“…Six of eight participants with contact allergy to Al reported previous atopic dermatitis and four of those six were in the exposed group. In sum, the Netterlid et al (2013) study demonstrated a 3.9% proportion of Al contact allergy in atopic individuals with allergic disease. Among those who developed Al-induced allergic reactions, children and adults with atopic dermatitis were more highly represented.…”

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 67%

“…Netterlid et al (2013) conducted a randomized, controlled, single-blind study of Al contact allergy. This was a multicentre evaluation of children and adults that involved patch-testing with allergen extracts containing Al(OH) 3 and AlCl 3 •6H 2 O in white petrolatum at 2.0, 10.0, and 20.0% w/w.…”

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

“…These reactions can develop weeks, months, or even years after injection of an Al-containing vaccine (Leventhal et al 2012). Histological examinations of biopsies from the injection sites revealed granulomatous and foreign body reactions (Garcia-Patos et al 1995) and people with hypersensitivity to Al-containing vaccines generally demonstrate positive patch testing to Al (Bergfors and Trollfors 2012, Beveridge et al 2011, Lehman et al 2008, Netterlid et al 2013). …”

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

318

203

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Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability.Address for correspondence: Calvin C. Willhite, Risk Sciences International, 55 Metcalfe Street, Suite 700, Ottawa, ON, Canada. calvinwillhite@hotmail.com. Declaration of interestPartial funding for this work was provided by a contract to review the recent scientific literature on health effects of aluminum between the International Aluminium Institute (IAI, www.world-aluminium.org), the Aluminium Reach Consortium (ARC, www.aluminium-reach-consortium.eu), and Risk Sciences International (RSI, www.risksciences.com), a Canadian company established in 2006 in partnership with the University of Ottawa. Additional financial support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) to D. Krewski, who holds the NSERC Chair in Risk Science at the University of Ottawa. C.C. Willhite, N.A. Karyakina, F. Momoli, and N. Yenugadhati were compensated by RSI for their contributions to the review. I. Arnold, T. Wisniewski and R. Yokel received no compensation from RSI for their contributions to this work. The authors, whose affiliations are shown on the title page, had sole responsibility for preparation of this paper, including determining the strategy for reviewing the scientific literature summarized in this article, synthesizing the findings, and drawing conclusions. Scientists associated with IAI/ARC were given the opportunity to review and offer technical comments on the paper, prior to submission to Critical Reviews in Toxicology. I. Arnold serves as a consultant to the International Aluminium Institute. None of the authors have appeared before regulatory agencies on behalf of the sponsors, or appeared as experts in legal proceedings concerning matters reviewed in this paper. The scientific opinions and conclusions expressed in the paper are exclusively those of the authors, and are independent of the sources of financial support. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptThe present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

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Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 67%

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

Section: Immunology and Vaccine Adjuvantsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts

Willhite¹,

Karyakina²,

Yokel³

et al. 2014

Critical Reviews in Toxicology

318

203

View full text Add to dashboard Cite

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“…Generally it is believed that the local inflammation due to a vaccine shot is important for induction of an efficient immune response. More recently, the induction of contact dermatitis to aluminium itself upon vaccination could be proven by skin testing in 5/78 children and 3/127 adults [57]. …”

Section: Reviewmentioning

confidence: 99%

Aluminium in Allergies and Allergen immunotherapy

Jensen‐Jarolim

2015

World Allergy Organization Journal

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Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT in the US, and SLIT in general, are at present non-adjuvanted therapies, but in Europe aluminium is used as adjuvant in most SIT preparations. It enhances the safety of SIT by local deposition of the allergen. Undesired properties of aluminium adjuvants comprise acute and chronic inflammation at the injection site, its Th2 immune stimulatory capacity, its accumulation besides biodistribution in the body. The adjuvant and safety profile of aluminium adjuvants in allergy vaccines are discussed, as well as the need for putting modern delivery systems and adjuvants on the fast track.

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“…Aluminum salts are used as adjuvants in vaccines against diphtheria, tetanus, and pertussis; hepatitis A and B; pneumococcal and meningococcal infections; and human papilloma virus . Persistent pruritic nodules after vaccinations have been reported since the 1960s, with later studies showing an association between these reactions and delayed‐type hypersensitivity to aluminum . Although aluminum hypersensitivity was previously believed to be rare, a Swedish study showed that of children presenting with persistent pruritic nodules secondary to receiving a vaccine containing an aluminum hydroxide adjuvant, 77% exhibited contact allergy to aluminum, as confirmed by patch testing .…”

Section: Discussionmentioning

confidence: 99%