Does a normal thyroid ultrasound image always accompany normal thyroid functions test results?

Tam, Abbas Ali; Kaya, Cafer; Üçler, Rıfkı; Dirikoç, Ahmet; Ersoy, Reyhan; Çakır, Bekir

doi:10.1530/endoabs.32.p1055

Cited by 4 publications

(5 citation statements)

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“…BRAFV600E, the most common gene mutation in PTC, is the strongest activator of the mitogen-activated protein kinase pathway and closely related to tumor neovascularization and disease progression. Furthermore, it is only found in PTC, not in other benign or malignant thyroid tumors 30–38 . These factors all aid in the differential diagnosis of PTC and can provide guidance for determining the clinical stage and prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it is only found in PTC, not in other benign or malignant thyroid tumors. [30][31][32][33][34][35][36][37][38] These factors all aid in the differential diagnosis of PTC and can provide guidance for determining the clinical stage and prognosis. In addition, BRAFV600E has been suggested to be the only independent factor for a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma

Ran

Zhou

2023

Ultrasound Quarterly

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This prospective study aimed to investigate the combination of shear wave elastography (SWE) and BRAFV600E mutation testing for the diagnosis of papillary thyroid carcinoma (PTC). One hundred thyroid nodules with an American College of Radiology thyroid imaging reporting and data system classification of 4 or 5 were subjected to SWE measurement, BRAFV600E genotyping, fine-needle aspiration, and surgery. Nonparametric statistical tests were used to compare the differences in the elastic parameters and BRAF genotypes between benign and malignant thyroid nodules of PTC, and receiver operating characteristic curve analysis was conducted to compare the diagnostic efficacy. In addition, the correlations between elastic parameters and BRAFV600E mutation in PTC were analyzed using binary logistic regression. The SWE, BRAFV600E, and their combination exhibited sensitivities of 72.9%, 81.3%, and 85.4%, respectively, and specificities of 66.7%, 90.3%, and 86.5%, respectively, in the diagnosis of PTC (P < 0.05). The SWE, BRAFV600E, and their combination exhibited sensitivities of 50.0%, 24.1% and 56.3%, respectively, and specificities of 89.7%, 87.5% and 82.8%, respectively, in the diagnosis of central cervical lymph node metastasis (P < 0.05). The combined use of SWE and BRAFV600E detection had the largest area under the curve, indicating that this combination is more effective in diagnosing PTC and lymph node metastasis in the central region than either method alone. Furthermore, Emax was positively associated with the BRAFV600E genotype. In conclusion, the combination of SWE and BRAFV600E genotype detection can improve the diagnostic efficacy for PTC. Emax can predict the BRAFV600E mutation status.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma

Ran

Zhou

2023

Ultrasound Quarterly

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“…Blood levels of TSH, TSH-receptor antibodies (TRAB), anti-TPO-antibodies (TPOAb) and anti-Thyroglobulinantibodies (TgAb) were analyzed using chemiluminescence immunometric assays (Immulite, Siemens Medical Solutions, Los Angeles, CA; USA) using the following reference values: TSH= 0.27-4.2 µIU/ml, TPOAb= 0-35 IU/ml, TgAb= 0-40 IU/ml, TRAB= 0-1,75 IU/ml. As the sonographic pattern is decisive in the evaluation of thyroid diseases and patients with normal ultrasound show a normal serology in more than 90% of cases [7][8], no blood work was performed in the control group.…”

Section: Methodsmentioning

confidence: 99%

Lymphadenopathy in Autoimmune Thyroiditis: Paratracheal Lymph Nodes are Indeed Crucial

Bouter¹

2017

OAJE

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Cervical lymphadenopathy is common in patients with autoimmune thyroiditis and supposed to be pathognomic for the disease if found in the paratracheal compartment (Robbins level VI). The aim of this prospective study is the extensive characterization of all cervical lymph node compartments in order to determine the significance of sonographic visible cervical lymphnodes in autoimmune thyroiditis. The study comprises 32 consecutive autoimmune thyroiditis patients and 32 controls without any thyroid pathologies. All patients underwent high resolution ultrasound and all visible lymph nodes were evaluated in all cervical levels by size, volume, S/L-ratio, appearance, vascularity and structural changes. In total, 84 lymph nodes in Robbins level VI were detected in the group of patients with autoimmune thyroiditis whereas the control group showed 2 positive lymph nodes. Lymph nodes in Robbins level VI were significantly smaller compared to lymph nodes in other cervical compartments with 54% of lymph nodes <5mm. Robbins level I-IV did not show any significant differences in the number of enlarged lymph nodes. S/L-ratio, vascularity and appearance was comparable in both groups in all cervical levels. In this prospective setting Robbins level VI could be identified as crucial lymph node level specific for autoimmune thyroiditis being pathognomic for the disease.

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“…Initial needle aspiration biopsy, although not routinely required for diagnosis, supports diagnosis in patients with negative antibodies. It is also necessary to rule out malignancy in patients with a single nodule 7 . As in all autoimmune diseases, there is harmful interaction of internal (genetic) and external (environmental) factors in the formation of Hashimoto's thyroiditis 6 .…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Hypothyroidism-Induced Autoantibodies, TSH Levels, and RDW, as an Inflammation Marker

AYGÜN

Gökdemir

Şişman³

et al. 2023

JoCASS

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Aim: Serum RDW grades were detected in patients with Hashimoto's thyroiditis. We aimed to use RDW to detect increased cardiovascular events in patients, increased oxidative stress, and inflammation without the need for an additional cost. Methods: We collected 904 persons results, 462 patients which have Hashimoto's thyroiditis, and 442 age and sex-matched control cases were comprised in our study. From laboratory measurements of the patients’ records were utilized such as hemogram, hs-CRP, fasting blood glucose, insulin, C-peptide, kidney function tests, liver function tests (ALT, AST), serum lipids (total cholesterol, triglyceride, HDL, LDL), anti-Tg, and anti-TPO, FT3, FT4, TSH levels. Results: RDW was considerably scaled up in case group compared to control group (Hashimoto's thyroiditis =10.08 ± 4.48%, control = 8.95 ± 6.68%, p <0.05). Also, MPV was increased in the study group(p<0.05). hs-CRP showed a statistically significant positive correlation between the level of RDW. Conclusion: Although the exact mechanism is still not fully understood, increased RDW levels in individuals with Hashimoto’s thyroiditis, possibly related to ongoing subclinical inflammation, neurohumoral activation, and changes resulting from oxidative stress in such patients. RDW is potentially a valuable tool for assessing cardiovascular diseases among patients diagnosed with Hashimoto's thyroiditis.

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Does a normal thyroid ultrasound image always accompany normal thyroid functions test results?

Cited by 4 publications

References 0 publications

Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma

Application of Ultrasound Shear Wave Elastography Combined With BRAFV600E Mutation for the Diagnosis of Papillary Thyroid Carcinoma

Lymphadenopathy in Autoimmune Thyroiditis: Paratracheal Lymph Nodes are Indeed Crucial

The Relationship Between Hypothyroidism-Induced Autoantibodies, TSH Levels, and RDW, as an Inflammation Marker

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