Does a melatonin supplement alter the course of gastro-esophageal reflux disease?

Madalinski, Mariusz

doi:10.4292/wjgpt.v2.i6.50

Cited by 7 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our observation is keeping with the previous studies in humans showing that the co‐administration of melatonin administered as the ‘safe adjuvant’ significantly increased the efficacy of ranitidine and PPI omeprazole or pantoprazole in amelioration of gastric and esophageal ulcerations . Part of these beneficial effects of melatonin could be ascribed to the inhibitory effect of melatonin of gastric acid secretion as reported by our group before .…”

Section: Discussionsupporting

confidence: 92%

“…Melatonin exhibits potent antioxidative effects by directly scavenging reactive oxygen species and indirectly through the stimulation of antioxidative enzymes in the gastrointestinal mucosa . We previously reported that melatonin is effective in promoting gastroprotection and accelerating healing of gastric ulcer and it also improves the healing of esophageal ulcers in humans . In the study of Kandil et al.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis

Konturek

Brzozowska

Targosz

et al. 2013

Journal of Pineal Research

View full text Add to dashboard Cite

Reflux esophagitis is a common clinical entity in western countries with approximately 30% of the population experiencing the symptoms at least once every month. The imbalance between the protective and aggressive factors leads to inflammation and damage of the esophageal mucosa. We compared the effect of exogenous melatonin and melatonin derived endogenously from L-tryptophan with that of pantoprazole or ranitidine in acid reflux esophagitis due to ligation of the rat pylorus and the limiting ridge between the forestomach and the corpus. Four hours after the induction of gastric reflux, an increase in mucosal lesions associated with edema of the submucosa and with the infiltration of numerous neutrophils and the fall in esophageal blood flow (EBF) were observed. Both melatonin and L-tryptophan or pantoprazole significantly reduced the lesion index (LI) and raised the EBF. Pinealectomy that significantly decreased plasma melatonin levels aggravated LI and these effects were reduced by melatonin and L-tryptophan. Luzindole, the MT2 receptor antagonist, abolished the melatonin-induced reduction in LI and the rise in EBF. L-NNA and capsaicin that augmented LI and decreased EBF, also significantly reduced melatonin-induced protection and hyperemia; both were restored with L-arginine and calcitonin gene-related peptide (CGRP) added to melatonin. Upregulation of IL-1β and TNF-α mRNAs and plasma IL-1β and TNF-α levels were significantly attenuated by melatonin and L-tryptophan. We conclude that melatonin protects against acid reflux-induced damage via activation of MT2 receptors mediated by NO and CGRP released from sensory nerves and the suppression of expression and release of TNF-α and IL-1β.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis

Konturek

Brzozowska

Targosz

et al. 2013

Journal of Pineal Research

View full text Add to dashboard Cite

show abstract

“…Thus, this study suggested that melatonin application in RE patients might be of potential clinical benefit in strengthening the integrity and permeability of surface epithelial esophageal cells [ 86 ]. This notion can be supported by the fact that older people are at a higher risk of complications from persistent RE due to the fall in melatonin production in elderly patients [ 87 , 88 ]. It is also of interest that patients presenting with upper digestive tract disorders such RE or duodenal ulcer show reduced plasma levels of melatonin [ 89 ].…”

Section: Role Of Melatonin In Esophagoprotection and Prevention Ofmentioning

confidence: 99%

Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives

Majka

Wierdak

Brzozowska

et al. 2018

IJMS

View full text Add to dashboard Cite

Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This “sleep” hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This indoleamine can protect the organs against a variety of damaging agents via multiple signaling. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. Since both of these condition are also identified as major risk factors for esophageal carcinoma, we provide some experimental and clinical evidence that supplementation therapy with melatonin could be useful in esophageal injury by protecting various animal models and patients with GERD from erosions, Barrett’s esophagus and neoplasia. The physiological aspects of the synthesis and release of this indoleamine in the gut, including its release into portal circulation and liver uptake is examined. The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed.

show abstract

“…Since its discovery, further investigation has revealed that it is also produced by several other organs. It has been found in the gastrointestinal tract [3], brain [4], eye [5], lungs [6], skin [7], kidney [8], liver [9], thyroid, thymus, pancreas [10], immune system [11] and reproductive system [12]. Melatonin is an indoleamine, which is synthesised from the essential amino acid, tryptophan [13].…”

Section: Melatonin: Synthesis and Degradationmentioning

confidence: 99%

Melatonin: shedding light on infertility? - a review of the recent literature

Fernando

Rombauts

2014

Journal of Ovarian Research

View full text Add to dashboard Cite

In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-014-0098-y) contains supplementary material, which is available to authorized users.

show abstract

Does a melatonin supplement alter the course of gastro-esophageal reflux disease?

Cited by 7 publications

References 7 publications

Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis

Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis

Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives

Melatonin: shedding light on infertility? - a review of the recent literature

Contact Info

Product

Resources

About