Does A.M. Have a Tumour in the Pancreas?

Gutteck-Amsler, Ursula; Rentsch, Katharina

doi:10.2533/chimia.2007.199

Cited by 2 publications

(3 citation statements)

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“…The adjunctive use of neuromuscular blocking drugs makes it possible to achieve an adequate muscle relaxation for all types of surgical procedures without the cardiorespiratory depressant effects of deep anesthesia [1][2][3]. Several analytical methods have been reported for the analysis of VB in biological fluids and pharmaceutical preparations, and these include LC-MS [4][5][6][7][8][9], LC with electrochemical detection [10,11], LC by using solid phase extraction with post-column ion-pair extraction and fluorimetric detection [12], and capillary gas chromatography by using nitrogen sensitive detection [13]. Its final degradation product (3,17-desacetyl vecuronium) is via hydrolysis hence the aim of this research was to develop and validate two simple and reliable analytical methods for the quantitative determination of VB in pharmaceuticals by separating its final degradation product as well as to compare the performance of chromatographic and electrophoretic techniques.…”

Section: Introductionmentioning

confidence: 99%

“…Vecuronium bromide (VB) is a nondepolarizing neuromuscular blocking agent; it is chemically designated as [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-Acetyloxy-10, 13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2, 3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate bromide. VB presents all pharmacological actions of the curare, in addition; this drug interferes in the transmission of neuromuscular end plate and causes diminished central nervous system activity.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Vecuronium Bromide in Pharmaceuticals: Development, Validation and Comparative Study of HPLC and CZE Analytical Methods

et al. 2011

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Vecuronium bromide is a neuromuscular blocking agent used for anesthesia to induce skeletal muscle relaxation. HPLC and CZE analytical methods were developed and validated for the quantitative determination of vecuronium bromide. The HPLC method was achieved on an amino column (Luna 150 9 4.6 mm, 5 lm) using UV detection at 205 nm. The mobile phase was composed of acetonitrile:water containing 25.0 mmol L -1 of sodium phosphate monobasic (50:50 v/v), pH 4.6 and flow rate of 1.0 mL min -1 . The CZE method was achieved on an uncoated fused-silica capillary (40.0 cm total length, 31.5 cm effective length and 50 lm i.d.) using indirect UV detection at 230 nm. The electrolyte comprised 1.0 mmol L -1 of quinine sulfate dihydrate at pH 3.3 and 8.0% of acetonitrile. The results were used to compare both techniques. No significant differences were observed (p [ 0.05).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Vecuronium Bromide in Pharmaceuticals: Development, Validation and Comparative Study of HPLC and CZE Analytical Methods

et al. 2011

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“…Electrospray ionization is a suitable technique for the detection of the compounds which have the lack of volatility, thermal stability, and the presence of quaternary amine moieties [11][12][13][14][15][16][17][18][19]. Therefore, it is very suitable to use ESI-MS technique for determination of CHD and NPEOn.…”

Section: Introductionmentioning

confidence: 98%