Dodecafluoropentane nanoemulsions produced with protein and lipid surfactants permit targeted oxygen and drug delivery, and help elucidate mechanisms of action

Borrelli, Michael J.; Hamilton, E.; Bernock, Laura J.

doi:10.1016/j.jvir.2013.12.029

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Nanomedicines For the Gas-carrier Component1

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2019

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“…As a carrier, DDFPe carries oxygen but also small molecule drugs at the same time. For example, thrombolytic drug tPA in a rabbit model of ischemic stroke or ischemic stroke (Nishioka et al, 1997; Borrelli et al, 2014). After targeted binding to blood clots suspended in the flow chamber, ultrasound was used to release oxygen or drugs.…”

Section: Nanomedicines For the Gas-carrier Componentmentioning

confidence: 99%

Nanomedicines: A Potential Treatment for Blood Disorder Diseases

Zhang

Wei

2019

Front. Bioeng. Biotechnol.

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Blood disorder diseases (BDDs), also known as hematologic, is one of the diseases owing to hematopoietic system disorder. Chemotherapy, bone marrow transplantation, and stem cells therapy have been used to treat BDDs. However, the cure rates are still low due to the availability of the right type of bone marrow and the likelihood of recurrence and infection. With the rapid development of nanotechnology in the field of biomedicine, artificial blood or blood substitute has shown promising features for the emergency treatment of BDDs. Herein, we surveyed recent advances in the development of artificial blood components: gas carrier components (erythrocyte substitutes), immune response components (white blood cell substitutes), and hemostasis-responsive components (platelet substitutes). Platelet-inspired nanomedicines for cancer treatment were also discussed. The challenges and prospects of these treatment options in future nanomedicine development are discussed.

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Section: Nanomedicines For the Gas-carrier Componentmentioning

confidence: 99%