DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA

Treatment of ocular disorders by gene therapy

“…These lipids may form complexes (so-called lipoplexes) with negatively charged nucleic acids [78]. Among lipid-based systems, liposomes and solid lipid nanoparticles (SLNs) are the preferred to deliver nucleic acids.…”

siRNA Delivery into Tumor Cells by Cationic Cholesterol Derivative-Based Nanoparticles and Liposomes

“…To overcome poor endosomal escape and subsequent degradation of siRNA in the late lysosomes, pH-sensitive lipids such as DOPE have been used as a component of liposomal siRNA vectors. 20,21) The role of DOPE is not fully understood, but it might affect the structural transition of cationic nanoparticles at the acidic pH of late endosomes in the cells. 22) Although the sizes and ζ-potentials of LP lipoplexes were similar with those of NP nanoplex (Table 1), LP lipoplex exhibited gene silencing effect in the cells (Fig.…”

Vaginal gene therapy

“…These lipids can bind electrostatically nucleic acids to form complexes named lipoplexes [61]. Among lipid-based systems, liposomes and solid lipid nanoparticles (SLNs) are the most representative lipid-based systems to deliver nucleic acids.…”