Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia

Papadakis, Manolis; Manginas, Athanassios; Cotileas, P.; Demopoulos, Vassilios; Voudris, Vasilios; Pavlides, Gregory; Foussas, Stefanos; Cokkinos, Dennis V.

doi:10.1016/s0002-9149(01)01984-1

Cited by 92 publications

(86 citation statements)

References 9 publications

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“…Papadakis and coworkers, using the CTFC method, have demonstrated that coronary artery ectasia is associated with diminished coronary flow velocity (Papadakis et al 2001). Although coronary artery ectasia was not found in our patients, we suggest that SCF may play a role in the etiology of coronary ectasia.…”

Section: Discussioncontrasting

confidence: 55%

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Slow Coronary Flow is Associated with Carotid Artery Dilatation

Yiğit

Sezgin

Demircan

et al. 2006

Tohoku J. Exp. Med.

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Slow coronary flow (SCF) in a normal coronary angiogram is a wellrecognized clinical entity, but its etiopathogenesis remains unclear. Carotid intima-media thickness (CIMT) is a noninvasive marker of atherosclerosis. The aim of this study was to investigate the CIMT and diameter of carotid and coronary artery in relation to SCF. Twenty-four patients with angiographically diagnosed SCF (51 ± 7 years), and 26 agematched subjects with normal coronary flow (NCF) (52 ± 8 years) in the coronary angiography were enrolled. Coronary flow rates were documented by thrombolysis in myocardial infarction (TIMI) frame count (TFC), a simple method for evaluating coronary blood flow. Carotid and coronary artery diameters and CIMT were measured. Mean TFC was significantly higher in patients with SCF than in patients with NCF ( p < 0.001). There were no significant differences regarding maximum ( p = 0.84) and mean CIMT ( p = 0.61). On the other hand, carotid lumen ( p = 0.03) and coronary artery diameters ( p = 0.001) were significantly greater in patients with SCF than in subjects with NCF. There was a significant relation between mean coronary artery diameter and TFC ( p = 0.004, 95% CI for OR: 1.61-11.87). In conclusion, these findings suggest that CIMT is not altered in patients with SCF as compared with those with NCF. However, carotid and coronary artery diameters are increased in patients with SCF as compared to those with NCF. Because the common carotid artery can be assessed in nearly every patient, carotid artery dilatation may be used as an early indicator for SCF. slow coronary flow; carotid intima-media thickness; carotid artery diameter; coronary artery diameter

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Section: Discussioncontrasting

confidence: 55%

“…The abnormal dilatation of the epicardial vessels must be considered a feature of atherosclerotic damage to the coronary circulation. Indeed, increased mortality in association with coronary ectasia has been reported (Papadakis et al 2001). …”

Section: Discussionmentioning

confidence: 99%

Slow Coronary Flow is Associated with Carotid Artery Dilatation

Yiğit

Sezgin

Demircan

et al. 2006

Tohoku J. Exp. Med.

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“…Although the precise mechanism of endothelial dysfunction is not clear in CAE; changes in flow properties in the dilated segments with subsequent alterations in blood viscosity, activation of the coagulation system and distal coronary embolization of material originated in the ectatic segment may explain the possible underlying ischemia (4,5). Papadakis et al, (6) 39 reviewed the angiograms of 173 patients with ectasia, and found lower coronary flow velocities (by the TIMI [Thrombolysis in Myocardial Infarction] frame count method) in patients with isolated coronary ectasia compared with patients with obstructive CAD. Similarly, in a study by Gulec et al, (7) 46% of the 94 ectatic coronaries in 45 patients had impaired epicardial flow (TIMI 2 or less).…”

Section: Discussionmentioning

confidence: 99%

“…Recent reports have implicated aneurysmal coronary arteries seem to have impaired flow velocities, flow reserve and microvascular flow dynamics, which may lead to inducible myocardial ischemia even in the absence of epicardial obstructive disease (6,7).…”

Section: Introductionmentioning

confidence: 99%

The Levels of Asymmetric Dimethylarginine in Patients with Isolated Coronary Artery Ectasia

Erden

Sözen

et al. 2010

ELECTRON J GEN MED

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“…KAE, koroner kan akı-mında yavaşlamaya, türbülan akıma, trombüs ve endotel disfonksiyonuna neden olabilmektedir ve genellikle asemptomatiktir. Semptomatik olgular stabil anginadan akut miyokart enfarktü-süne kadar değişen klinik tablolar ile başvurabilmektedir (3)(4)(5).…”

Section: Introductionunclassified

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

Altıparmak

Kaya²,

Sezen³

et al. 2012

Anadolu Kardiyol Derg

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Objective: Coronary artery ectasia (CAE) is a congenital or acquired anomaly characterized with localized or diffuse dilatations of coronary arteries. Paraoxonase (PON-1) is a high-density lipoprotein-cholesterol (HDLC) associated antioxidant enzyme that prevents atherosclerosis. The aim of this study was to investigate serum paraoxonase-1 enzyme activity (SPA) in patients with CAE in comparison patients with coronary artery disease (CAD) and normal coronary arteries. Methods: We have evaluated 44 patients with isolated IKAE, 40 cases with normal coronary arteries (NCA), 40 cases with critical CAD (CAD) and 40 cases with minimal CAD (MCAD) in this cross-sectional observational study. Demographic and biochemical data of patients were collected. SPA was determined spectrophotometrically. Among-group comparisons, ANOVA, Kruskal-Wallis and Chi-square tests were used; Bonferroni test was used for post-hoc analysis, Pearson's correlation analysis to determine the parameters associated with the SPA. Results: There were no differences among groups with regard to age, sex, presence of diabetes, hypertension and smoking (p>0.05 for all). The highest HDLC was detected in patients with NCA and lowest HDLC was detected in patients with CAD (respectively 52±15 mg/dL; 41±16 mg/d L, p=0.021). CAD and CAE groups were similar with respect to HDLC levels (p>0.05). The highest SPA level was detected in patients 307 ÖZET Amaç: Koroner arter ektazisi (KAE), konjenital veya edinsel olabilen koroner arter dilatasyonlarıdır. Paraoksonaz, yüksek-dansiteli lipoprotein-kolesterol (HDLK) aracılı antioksidan bir enzimdir ve düşük-dansiteli lipoprotein-kolesterol (LDLK)'ü bakır iyonu ve serbest radikallerin indüklemiş olduğu oksidasyondan koruyarak aterosklerozun önlenmesinde rol oynar. Bu çalışmada amaç izole KAE (İKAE) olan hastalarla normal koronerleri olan ve KAH olan hastalarda serum paroksanaz-1 enzim aktivitesini (SPA) açısından fark olup olmadığını araştırmak idi. Yöntemler: Bu enine-kesitli gözlemsel çalışmaya İKAE'si bulunan 44 hasta ile birlikte minimal koroner arter hastalığı (MKAH) olan 40; kritik koroner darlığı olan (KAH) 40 ve normal koroner arterleri olan (NKA) 40 olgu dâhil edildi. Tüm olgularda demografik veriler ve biyokimyasal veriler yanında SPA spektrofotometrik olarak değerlendirildi. Gruplar arası karşılaştırmalarda ANOVA, Kruskal-Wallis ve Ki-kare testleri, post-hoc analizler için Bonferroni testi, SPA'nın ilişkili parametrelerin belirlenmesinde Pearson korelasyon analizi kullanıldı. Bulgular: İKAE ve diğer gruplar arasında, yaş, cinsiyet, diyabet, hipertansiyon varlığı ve sigara içiciliği açısından istatistiksel anlamlı fark yoktu (hepsi için p>0.05). Gruplar arasında HDLK yönünden fark vardı (p=0.021). En yüksek SPA NKA grubunda saptanırken en düşük SPA KAH grubunda saptandı (sırası ile 250.78±59.37U/L; 163.39±49.28 U/L; p=0.005). Post-hoc analizlerde bu farkın İKAE grubu ile NKA grubu ve KAH grubu ile NKA grubu arasında olduğu gözlendi [p=0.005 (NKA ve İKAE); p=0.0045 (NKA ve MKAH ); p=0.007 (NKA ve KAH)]....

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Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia

Cited by 92 publications

References 9 publications

Slow Coronary Flow is Associated with Carotid Artery Dilatation

Slow Coronary Flow is Associated with Carotid Artery Dilatation

The Levels of Asymmetric Dimethylarginine in Patients with Isolated Coronary Artery Ectasia

The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study

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