Document de consensus WAO–ARIA–GA2LEN sur le diagnostic allergologique moléculaire

Canonica, Giorgio Walter; Ansotegui, Ignacio J.; Pawankar, Ruby; Schmid‐Grendelmeier, Peter; Hage, Marianne van; Baena-Cagnani, Carlos E.; Melioli, Giovanni; Nunes, Carlos Pereira; Passalacqua, Giovanni; Rosenwasser, Lanny J.; Sampson, Hugh A.; Sastre, Joaquı́n; Bousquet, Jean; Zuberbier, Torsten; Allen, K.; Asero, Riccardo; Bohle, Barbara; Cox, L.; Blay, F. De; Maximiliano-Gomez, R.; González-Díaz, S.; Haahtela, Tari; Holgate, Stephen T.; Jakob, Thilo; Larché, Mark; Matricardi, Paolo Maria; Oppenheimer, John; Poulsen, Lars K.; Renz, Harald; Rosário, Nelson Maria; Rothenberg, Marc E.; Sánchez-Borges, Mario; Scala, Enrico; Valenta, Rudolf

doi:10.1016/j.reval.2014.10.001

Cited by 6 publications

(2 citation statements)

References 103 publications

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“…It has many advantages and results are close but not identical to classical immunoassays [10] (WAO Position Paper, in press). However, for some allergens [11][12][13] and for low IgE levels [14] it may not be sufficiently sensitive.…”

Section: Introductionmentioning

confidence: 99%

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

Lupinek

Wollmann

Baar

et al. 2014

Methods

225

259

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Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the MeDALL is a European research program in which allergen microarray technology is used for the monitoring of the development of allergic disease in childhood, to draw a geographic map of the recognition of clinically relevant allergens in different populations and to establish reactivity profiles which are associated with and predict certain disease manifestations. We describe technical advances of the MeDALL allergen-chip regarding specificity, sensitivity and its ability to deliver test results which are close to in vivo reactivity. In addition, the usefulness and numerous advantages of allergen microarrays for allergy research, refined allergy diagnosis, monitoring of disease, of the effects of therapies, for improving the prescription of specific immunotherapy and for prevention are discussed. Europe PMC Funders Group

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Section: Introductionmentioning

confidence: 99%

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

Lupinek

Wollmann

Baar

et al. 2014

Methods

225

259

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“…Component-resolved specific diagnosis is also important due to the high heterogeneity of geographically-related sensitization profiles. Moreover, molecular-based diagnosis improves the understanding of clinically relevant IgE sensitization to cross-reactive allergen components from aeroallergen sources and foods [8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Polcalcins as pollen panallergens in allergic rhinitis

Popescu

Vieru

2016

Romanian Journal of Rhinology

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Polcalcins are highly cross-reactive calcium-binding allergen components specifically expressed in pollen from trees, grasses and weeds. The grass allergen component rPhl p 7, a recombinant non-glycosylated calcium-binding protein of 2-EF-hand type, is the most cross-reactive polcalcin and may be used as a polcalcin biomarker of IgE-mediated hypersensitivity. Polcalcin sensitization, which appears to be linked to geographical factors, level and time of pollen exposure, has to be assessed in allergic rhinitis patients with multiple pollen sensitizations and may be useful for a better targeted prescription of allergen immunotherapy.

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