Medical students have difficulty calculating drug doses correctly, but better teaching improves their performance in written tests. We conducted a blinded, randomised, controlled trial to assess the benefit of online teaching on students' ability to administer drugs in a simulated critical incident scenario, during which they were scored on their ability to administer drugs in solution presented as a ratio (adrenaline) or percentage (lidocaine). Forty-eight final year medical students were invited to participate; 44 (92%) attended but only nine of the 20 students (45%) directed to the extra teaching viewed it. Nevertheless, the teaching module significantly improved the students' ability to calculate the correct volume of lidocaine (p = 0.005) and adrenaline (p = 0.0002), and benefited each student's overall performance (p = 0.0007). Drug administration error is a very major problem and few interventions are known to be effective. We show that focusing on better teaching at medical school may benefit patient safety. Medical students at our university had a poor understanding of different ways of expressing the concentrations of drugs in solution [1]. In a study conducted in 2002, we found that only 62.3% knew that a 1 : 1000 solution of adrenaline (epinephrine) contains 1 mg.ml )1 and only 37.6% knew that 1% lidocaine contains 10 mg.ml . There is evidence that this may be a global problem for medical students and doctors alike [2-5], and our past research has led us to recommend that ampoule labels be standardised to mass concentration, and education about drug administration improved [6].We recently reported the impact of an online teaching module designed to improve our medical students' drug dose calculation and administration skills [7]. The module consisted of interactive tutorials concerning pharmacokinetics, drug interactions and dose calculations, case studies, and the opportunity for self-assessment. The outcome measures were students' performances in regular written and practical assessments throughout their final year of study. The additional teaching improved students' understanding of drug administration, but the effect waned over time.In this study we examined the influence of improved education on the competence and efficiency of medical students to prescribe the correct amount of drugs to patients under more realistic conditions. Medical students in their final year of training were invited to participate in a critical care scenario carried out in a high fidelity patient simulator. The clinical scenario was devised to rely heavily on the use of drugs in solution. Use of the simulator enabled us not only to assess the competence with which the medical students were able to prescribe