Docosahexaenoic acid reverses the promoting effects of breast tumor cell-derived exosomes on endothelial cell migration and angiogenesis

SMAD4 contributes to chondrocyte and osteocyte development

“…Herein, we summarized some fundamental findings to show the molecular mechanisms whereby SMAD4 contributes to chondrogenesis and osteogenesis. Assuredly, in the future, more investigations can remove the veil of ignorance and answer to some open‐ended questions; for example, exosomes, membrane‐bound extracellular vesicles that carry the specific molecules, 131 contribute to the skeletal development 1 and bone repair 132 , 133 , 134 ; however, little is known about how exosomal SMAD4 or even related miRNAs and lncRNAs play roles during the skeletal development. Besides, it has been identified that taking medicines can also affect the expression and function of SMAD4, eg some studies discovered that valproic acid inhibited the SMAD4 expression by monoubiquitination in prostate carcinoma.…”

Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

“…Needless to say that if BC is diagnosed as early as possible, it improves the patients' life. 3,4 Among different imaging techniques that are used for BC diagnosis, mammography is still a gold standard technique. 5 This method, on the other hand, is problematic due to false-negative and/ or -positive diagnoses, required biopsy, low sensitivity, and imposing psychological stresses.…”

Extracellular vesicle-mediated transport: Reprogramming a tumor microenvironment conducive with breast cancer progression and metastasis

“…Ghaffari-Makhmalbaf et al. noted a significant reduction in human umbilical vein endothelial cells expression of VEGF-A, proliferation, and migration when treated with EVs derived from docosahexaenoic acid treated breast cancer cells [67] . Connecting the breast cancer cell profile to secreted EV expression, Aslan et al.…”