Docosahexaenoic acid reduced vascular endothelial cell injury in diabetic rats via the modulation of autophagy
Aysan Eslami Abriz,
Atefeh Araghi,
Mahdieh Nemati
et al.
Abstract:Purpose: Among varied ω-3 polyunsaturated fatty acid types, the therapeutic properties of Docosahexaenoic acid (DHA) have been indicated under diabetic conditions in different cell lineages. Here, we investigated the anti-diabetic properties of DHA in rats with type 2 diabetes mellitus (D2M) focusing on autophagy-controlling factors. Methods: D2M was induced in male Wistar rats using a single dose of Streptozocin (STZ) and a high-fat diet for 8 weeks. On week 2, diabetic rats received DHA 950 mg/kg/day until t… Show more
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