Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid β-infused rats relates to the decreases of amyloid β and cholesterol levels in detergent-insoluble membrane fractions

Hashimoto, Michio; Hossain, Shahdat; Agdul, Haqu; Shido, Osamu

doi:10.1016/j.bbalip.2005.11.011

Cited by 118 publications

(93 citation statements)

References 61 publications

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“…Amyloid peptides then precipitate, after conformational transformation, into insoluble proteic deposits as neuritic plaques and neurofibrillary tangles. DHA decreases amyloid levels in detergent-insoluble membrane fractions from the cortex of AD-model rats (93). Alterations in lipid raft and membrane composition, as well as in the fluidity of the membrane in synaptosomal preparations, have been well characterized in AD-model rats (62,93).…”

Section: Lipid Rafts and Dhamentioning

confidence: 99%

“…Amyloidogenesis involves interactions among amyloid peptides, cholesterol, saturated fatty acids, and sphingomyelin (92). Administration of DHA considerably decreases the levels of cholesterol, palmitic acid, and stearic acid in detergent-insoluble membrane fractions of AD-model rats (93), suggesting raft-destabilizing effects of DHA, which might induce the collapse of rafts and decrease the docking of amyloids onto raft platforms. DHA-induced increases in membrane fluidity (61,92,94) may help in exocytosis to relieve the amyloid burden.…”

Section: Lipid Rafts and Dhamentioning

confidence: 99%

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Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

Hashimoto

Hossain

2011

J Pharmacol Sci

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Abstract. Docosahexaenoic acid (DHA, C22:6 n-3), the most abundant n-3 polyunsaturated fatty acid in the brain, is essential for brain growth and development. Recent evidence has indicated the potential health benefits of DHA for managing Alzheimer's disease (AD). For example, dietary administration of DHA considerably protects against and ameliorates the impairment of learning ability in amyloid-beta (Aβ) 1-40 -infused AD-model rats, with concurrent increases in DHA levels and decreases in the levels of lipid peroxide and reactive oxygen species in the cortico-hippocampal tissues. In addition, dietary DHA helps in eliminating the amyloid burden from the brains of ADmodel rats. In vitro studies have revealed that DHA substantially inhibits Aβ fibrillation. Furthermore, DHA reduces amyloid-induced toxicity in cell culture. These in vitro data support the hypothesis that DHA can ameliorate the cognitive deficits of AD in vivo by limiting Aβ polymerization in the brains. Therefore, it might be a useful therapeutic agent to prevent and/or delay cognitive impairment in mild cases of AD.

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Section: Lipid Rafts and Dhamentioning

confidence: 99%

Section: Lipid Rafts and Dhamentioning

confidence: 99%

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

Hashimoto

Hossain

2011

J Pharmacol Sci

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“…Studies show that DHA may protect the brain by increasing glutathione reductase activity resulting in decreased accumulation of oxidized proteins, lipid peroxide and ROS levels [49]. Further, DHA also inactivates caspase activation signaling pathways [50], inhibits hyperphosphorylation of tau protein [51] and regulates the PI3K/Akt cascade.…”

Section: Omega-3 Polyunsaturated Fatty Acids (Pufas)mentioning

confidence: 99%

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

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Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

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“…The pretreatment of rats with DHA protected the animals against the memory loss which typically occurs when they are infused with Alzheimer disease Aβ peptide, which triggers a synapse loss (Coleman & Yao, 2003). DHA inhibits the accumulation of insoluble Aβ peptide, partially by decreasing cholesterol levels in the detergent insoluble membrane domains (rafts) of the cerebral cortex (Hashimoto et al, 2005). It has been recently demonstrated that the effect of DHA in the reduction of insoluble Aβ peptide is attributable to a decrease in the steady-state levels of presenilin 1 (Green, et al, 2007).…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Docosahexaenoic acid (DHA), an essential fatty acid for the proper functioning of neuronal cells: their role in mood disorders

Valenzuela

2009

Grasas y Aceites

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Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid β-infused rats relates to the decreases of amyloid β and cholesterol levels in detergent-insoluble membrane fractions

Cited by 118 publications

References 61 publications

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer’s Disease

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Docosahexaenoic acid (DHA), an essential fatty acid for the proper functioning of neuronal cells: their role in mood disorders

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