Docosahexaenoic acid (cervonic acid) incorporation into different brain regions in the awake rat

Sarda, Nicole; Gharib, Abdallah; Molière, Patrick; Grange, Eric; Bobillier, Pierre; Lagarde, Michel

doi:10.1016/0304-3940(91)90157-o

Cited by 23 publications

(13 citation statements)

References 12 publications

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“…1 ), also exhibits low affinities for its substrates (K m = 200 M and K m = 150 M ) [Cornell, 1992], when compared with brain levels of these compounds of approximately 10 M [Cansev et al, 2005] and approximately 75 M [Abe et al, 1987], respectively. The affinities of CPT for DAG and CDP-choline are decreased if the DAG contains a polyunsaturated fatty acid; this, in turn, would decrease the substrate saturation of CPT [Mantel et al, 1993] and allow DAGs rich in polyunsaturated fatty acid to be preferentially utilized for phosphatide synthesis, as has been shown to be the case [DeGeorge et al, 1991;Sarda et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

“…It is incorporated into the sn-2 position of DAG ( fig. 1 ); DAG species that are rich in DHA are preferentially incorporated into membrane phospholipids [DeGeorge et al, 1991;Sarda et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

“…It is incorporated into the sn-2 position of some diacylglycerol (DAG) moieties ( fig. 1 ), and DAG rich in DHA are preferentially incorporated into membrane phospholipids [DeGeorge et al, 1991;Sarda et al, 1991]. DHA-containing phosphatides can be deacylated and then reacylated with other fatty acids [Tou, 1986], hence steady-state membrane DHA levels underreflect the quantities of DHA initially incorporated.…”

Section: Introductionmentioning

confidence: 99%

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Giving Uridine and/or Docosahexaenoic Acid Orally to Rat Dams during Gestation and Nursing Increases Synaptic Elements in Brains of Weanling Pups

et al. 2009

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Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5′-monophosphate) and docosahexaenoic acid supplementation on pups’ brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Giving Uridine and/or Docosahexaenoic Acid Orally to Rat Dams during Gestation and Nursing Increases Synaptic Elements in Brains of Weanling Pups

et al. 2009

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“…These anomalies suggest a neurological abnormality at or just before the neural generator of the P2 wave (the cochlear nucleus). Sarda et al [39] found that DHA incorporation into the developing rat was especially high in the cochlear nucleus and other structures along the brainstem's auditory pathway.…”

Section: Effects On the Abrmentioning

confidence: 99%

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Church

Jen

Stafferton

et al. 2007

Neurotoxicology and Teratology

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Consumption of the nutrients omega-3 fatty acids (ω-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that over-supplementation with ω-3 FA, especially in the form of fish oil, can have adverse effects on fetal and infant development and the auditory brainstem response (ABR). Our goal was to assess further the effects of ω-3 FA excess and deficiency during pregnancy and lactation on the offspring's auditory acuity as evidenced by their ABR thresholds. Female Wistar rats were given diets that were either deficient, adequate (control) or excess in ω-3 FA from day 1 of pregnancy through lactation. The offspring were ABR-tested at the postnatal age of 24 days. The rat pups in the Excess treatment condition had significantly elevated (worse) ABR thresholds, postnatal growth restriction, and a trend for increased postnatal mortality in comparison to the Control group. The Deficient group was intermediate. In conclusion, excess or deficient amounts of ω-3 FA during pregnancy and lactation in the laboratory rat adversely affected the offspring's auditory acuity. Postnatal thriving was also adversely affected. Consuming or administering large or inadequate amounts of ω-3 FA during pregnancy and lactation seems inadvisable because of the potential for adverse effects on infant development.

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“…Exogenously administered AA, like DHA, is preferentially incorporated into brain phosphatides [131,132], as well as into other lipids, e.g. the plasmalogens [133,134].…”

Section: Availability Of Dha and Other Pufa To Brain Cellsmentioning

confidence: 99%

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses

Cansev

Wurtman

Sakamoto

et al. 2007

Alzheimer's & Dementia

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Although cognitive performance in humans and experimental animals can be improved by administering the omega-3 fatty acid docosahexaenoic acid (DHA), the neurochemical mechanisms underlying this effect remain uncertain. In general, nutrients or drugs that modify brain function or behavior do so by affecting synaptic transmission, usually by changing the quantities of particular neurotransmitters present within synaptic clefts or by acting directly on neurotransmitter receptors or signal-transduction molecules. We find that DHA also affects synaptic transmission in mammalian brain: Brain cells of gerbils or rats receiving this fatty acid manifest increased levels of phosphatides and of specific pre-or post-synaptic proteins. They also exhibit increased numbers of dendritic spines on postsynaptic neurons. These actions are markedly enhanced in animals that have also received the other two circulating precursors for phosphatidylcholine -uridine (which gives rise to brain UTP and CTP), and choline (which gives rise to phosphocholine). The actions of DHA are reproduced by eicosapentaenoic acid (EPA), another omega-3 compound, but not by the omega-6 fatty acid arachidonic acid (AA). Administration of circulating phosphatide precursors can also increase neurotransmitter release (acetylcholine; dopamine) and affect animal behavior. Conceivably, this treatment might have use in patients with the synaptic loss that characterizes Alzheimer's disease or other neurodegenerative diseases, or occurs after stroke or brain injury.

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Docosahexaenoic acid (cervonic acid) incorporation into different brain regions in the awake rat

Cited by 23 publications

References 12 publications

Giving Uridine and/or Docosahexaenoic Acid Orally to Rat Dams during Gestation and Nursing Increases Synaptic Elements in Brains of Weanling Pups

Giving Uridine and/or Docosahexaenoic Acid Orally to Rat Dams during Gestation and Nursing Increases Synaptic Elements in Brains of Weanling Pups

Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses

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