Docking Study of Novel N-Substituted 2,5-Bis[(7-Chloroquinolin-4-Yl)amino]pentanoic Derivatives as Selective High-Binder With Angiotensin Converting Enzyme 2
Abstract:The prevalence of a novel coronavirus (2019-nCoV) in the last few months represents a serious threat as a world health emergency concern. Angiotensin-converting enzyme 2 (ACE2) is the host cellular receptor for the respiratory syndrome of coronavirus epidemic in 2019 (2019-nCoV). In this work, the active site of ACE2 is successfully located by Sitmap prediction tool and validated by different marketed drugs. To design and discover new medical countermeasure drugs, we evaluate a total of 184 molecules of 7-chlo… Show more
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