Docking Studies of Some Novel Hetrocyclic Compound as Acat Inhibitors: A Meta Analysis

The limitations and negative effects of current therapeutic techniques for brain tumors necessitate the selection of alternative therapeutic options. Therapeutic hydrogel systems that are monitored by magnetic resonance imaging (MRI) are one alternative for neurosurgical treatment of brain tumors that does not need any invasive procedures. There is a significant deal of potential for the treatment of brain tumors that can be attributed to the specific physical and chemical properties that hydrogels possess. The ability to encapsulate therapeutic molecules, provide regulated and sustained drug release, and successfully pass the blood-brain barrier are some of the properties that are included in this category. By combining hydrogel systems with magnetic resonance imaging (MRI) capabilities, it is possible to design therapeutic approaches that provide regulated release of therapeutic medications and real-time monitoring possibilities. Despite the fact that surgical resection is still extremely important, there is a growing demand for alternatives that can supplement or even replace it. Within the scope of this narrative review, the therapeutic hydrogel systems that are monitored by magnetic resonance imaging (MRI) will be evaluated to determine their potential for the non-surgical treatment of brain tumors.

Section: Chemotherapymentioning

confidence: 99%

Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors: A Systematic Review

Kumar,

Kumari,

Suthar

et al. 2024

“…The bulk of the hydroxycinnamic acids in hops are composed of caffeine, ferulic acid, and sinapic acid, while the majority of the hydroxybenzoic acids are composed of gallic acid, syringic acid, and vanillic acid [94,95]. The bitter acid equivalents humulone and lupulone are the most prevalent phloroglucinol derivatives found in hops [96,97]. Bitter acids come in two different varieties: humulone-derived -acids and -acids (derived from lupulone).…”

Section: Humulus Lupulus Lmentioning

confidence: 99%

Plants Alkaloids Based Compound as Therapeutic Potential for Neurodegenerative

Patel¹,

Gangwar²,

Gupta³

et al. 2023

Although while getting a restful night's sleep is essential for your mental and physical health, insomnia is very prevalent. More people are turning to complementary and alternative therapies to treat or prevent sleeplessness. For hundreds of years, herbal treatments like valerian, passionflower, lemon balm, lavender, and California poppy have been utilized successfully. After using these herbal medicines, sleep latency was reduced and subjective and objective measures of sleep quality improved. Their sedative and sleep-inducing effects are caused by interactions with several neurotransmitter systems in the brain, according to molecular research. The plant species can be divided into 76 different genera and 32 different families, with the Asteraceae (24.2%) and Lamiaceae (21.1%) being the most prevalent subgroups. Leaves (29%) and flowers (27%), respectively, are used to make the majority of infusions (70%) and decoctions (25%). Just the most well-known taxa—out of the 106 known—are treated here (A. arvensis L., C. nepeta L., C. monogyna Jacq., H. lupulus L., L. nobilis L., L. angustifolia Mill., M. sylvestris L., M. chamomilla L., M. officinalis L., O. basilicum L., P. rhoeas L., P. somniferum L., R. officinalis L., T. platyphyllus Scop., and V. officinalis L.). Further study is required to confirm the therapeutic potential of these substitutes and define the mechanism of action of bioactive compounds because only seven of the fifteen species chosen have been investigated for pharmacological activity as hypnotic-sedatives.

“…[101] Figure 5: Chemical constituents of Ginkgo biloba L G. biloba L. is considered a neuroprotective agent as it possesses antioxidant, anti-inflammatory and vasoregulatory actions and has been proposed in the treatment of glaucoma. [102,103,104] It acts by stabilizing the mitochondria as there are abnormal mitochondrial changes that make the retinal ganglion cells more susceptible to oxidative stress. In a study, it was found that G. biloba L. decreases the level of reactive oxygen species and protects the mitochondrial membrane in cultured neuronal cells.…”

Section: Foeniculum Vulgare Millmentioning

confidence: 99%

Recent Approaches of Ocular Disease and Its Herbal Product Treatment: An Updates

Butola¹,

Bisht²,

Kumar³

2023

One of the most common causes of permanent vision loss is glaucoma. Damage to the optic nerve and retinal ganglion cells, the root cause of visual field impairment, is typically the result of elevated intraocular pressure. Some patients' illness worsens even when treated with eye medications that reduce intraocular pressure. The pathophysiology of glaucoma is not only thought to involve mechanical and vascular dysfunctions of the eye, but also oxidative stress, neuroinflammation, and excitotoxicity. Therefore, natural compounds with antioxidant and anti-inflammatory qualities may offer a different strategy for treating glaucoma. This review summarizes the most up-to-date preclinical and clinical research on natural compounds that have been proven to contain neuroprotective characteristics for retinal ganglion cells and, consequently, may be useful in the treatment of glaucoma. Baicalein, forskolin, marijuana, ginsenoside, resveratrol, and hesperidin are all effective at lowering intraocular pressure. On the other hand, antioxidant, anti-inflammatory, and anti-apoptosis mechanisms are among those through which Ginkgo biloba, More research is needed to determine whether natural items can be used as a safe and effective treatment for glaucoma.