Abstract:Tropomyosin‐related kinase A (TrkA) serves as a promising target protein for the development of anticancer medicines. We report new TrkA inhibitors of natural origin identified from the structure‐based virtual and biochemical screening. A proper molecular hydration term was implemented into the original free energy function to perform virtual screening with an improved accuracy. As a consequence, four natural TrkA inhibitors were found with IC50
values ranging from 3 to 70 μM. The good biochemical efficacies … Show more
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