Docetaxel-induced photolichenoid eruption

Vasudevan, Biju; Sawhney, Mps; Sharma, Nitu

doi:10.4103/0253-7613.56065

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Nail pigmentation for cyclophosphamide, photolichenoid eruption for docetaxel, pancreatitis (Imatinib), panic attacks (Ifosfamide) and Capecitabine induced oral pigmentation and hand-foot syndrome. 3,[6][7][8][9] There is a dearth of ADRs data associated with chemotherapy drugs in countries like India and a systematic pharmacovigilance study on cancer chemotherapy has not been previously done in our setup.…”

Section: Introductionmentioning

confidence: 99%

Prospective observational study to evaluate the pattern of adverse drug events in cancer patients receiving anti-cancer agents in a tertiary care hospital

Joshi

Kadhe

2016

Int J Basic Clin Pharmacol

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Background: Adverse drug reactions (ADRs) associated with the use of anticancer drugs are a worldwide problem and cannot be overlooked. They range from nausea, vomiting or any other mild reaction to severe myelosuppression. The study was planned to evaluate the pattern of adverse drug events to anti-cancer agents in a tertiary care hospital. Methods: This observational prospective study was carried out in a tertiary care hospital from 1st January 2011 to 31st December 2011. A total of 213 patients who fulfilled the inclusion criteria were enrolled in the study. Out of them, 8 patients were withdrawn from the study as they subsequently underwent radiotherapy. The adverse events observed during the treatment were noted and analyzed by using applicable statistics. Results: Out of 205 patients, 98 were males and 107 were females. Breast cancer was the commonest type of cancer evident. A total 523 anti-cancer drugs were prescribed for the patients with alkylating agents being the most common. 635 adverse events (ADRs) were observed in patients with vomiting and nausea as the most common adverse drug reactions (ADREs). Majority of the ADRs (89%) had a latent onset (occurring 2 or more days after exposure to the drug). Few events were serious in nature (9%); fatal events were uncommon (0.31%). WHO causality was 'possible' for 94% of the events. ADRs were more frequently observed in females in the age group of 46-60 years; mood swings were significantly higher in women, while vomiting was found to be significantly common in men. Conclusions: The study showed that chemotherapy has a high potential to cause ADRs. Thus, there is a need for vigilant ADR monitoring to prevent morbidity and mortality due to ADRs.

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Section: Introductionmentioning

confidence: 99%

Prospective observational study to evaluate the pattern of adverse drug events in cancer patients receiving anti-cancer agents in a tertiary care hospital

Joshi

Kadhe

2016

Int J Basic Clin Pharmacol

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“…Side effects of docetaxel include neutropenia, anemia, thrombocytopenia, and minor rash to severe anaphylaxis reactions, which are reversible on stopping treatment. In literature, various skin reactions reported includes maculopapular drug rash, alopecia, nail hyperpigmentation and destruction, onycholysis, palmar–plantar erythrodysesthesia, cutaneous lupus and scleroderma, 3 photolichenoid eruption, 4 erythema multiforme major, 5 and persistent serpentine supravenous hyperpigmented eruption. 6…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Life-Threatening Extensive Mucocutaneous Adverse Reaction Induced by Docetaxel in a Breast Cancer Patient: Toxic Epidermal Necrolysis, a Case Report with Review of Literature

Shrivastava

Elhence

Jinwala

et al. 2022

Indian J Med Paediatr Oncol

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Fever and extensive necrosis with 30% or more epidermal involvement along with mucous membrane is known as toxic epidermal necrolysis (TEN). It is a life-threatening mucocutaneous disease and is usually drug induced. We report a rare case of docetaxel-induced TEN. A patient with metastatic breast carcinoma received single agent docetaxel and developed severe skin and mucous membrane reaction involving more than 30% of the skin, and managed conservatively in intensive care unit but she succumbed to her illness. Although common toxicities reported with docetaxel include alopecia, nail damage, myelosuppression, and erythema multiforme major, TEN after docetaxel is very rare and can be a life-threatening complication as in our case.

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“…However, many cutaneous adverse effects including erythematous pruritic maculopapular eruption, PPES, hyperpigmentation, photolichenoid eruption, and nail changes have been observed in 50-70% of the treated patients. [ 4 5 ] Since the skin toxicity is self-limiting and usually resolves in 1-2 weeks, cessation of docetaxel treatment is rarely required.…”

Section: Discussionmentioning

confidence: 99%

Docetaxel-induced palmoplantar erythrodysesthesia syndrome and long-lasting multiple nail changes

Akoğlu¹

2014

Indian J Pharmacol

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Palmoplantar erythrodysesthesia syndrome (PPES) and nail changes are common presentations of cutaneous toxicity of docetaxel chemotherapy, which deteriorate the quality of life of patients. Herein, we describe a female patient who developed PPES and multiple nail changes due to docetaxel treatment for infiltrative ductal carcinoma. Cold application and elevation of extremities during docetaxel infusion, potent topical steroids and oral pyridoxine increased the tolerance to chemotherapy and provided regression of painful cutaneous lesions without cessation of the treatment.

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Docetaxel-induced photolichenoid eruption

Cited by 7 publications

References 6 publications

Prospective observational study to evaluate the pattern of adverse drug events in cancer patients receiving anti-cancer agents in a tertiary care hospital

Prospective observational study to evaluate the pattern of adverse drug events in cancer patients receiving anti-cancer agents in a tertiary care hospital

A Rare Case of Life-Threatening Extensive Mucocutaneous Adverse Reaction Induced by Docetaxel in a Breast Cancer Patient: Toxic Epidermal Necrolysis, a Case Report with Review of Literature

Docetaxel-induced palmoplantar erythrodysesthesia syndrome and long-lasting multiple nail changes

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